{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:57:55Z","timestamp":1767981475446,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["45\/2\/2010\/Immunology\/BMS"],"award-info":[{"award-number":["45\/2\/2010\/Immunology\/BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>The study was carried out to study expression of Toll like receptors 2 (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2), natural\/inducible Treg and Interferon\u2010\u03b3 alongside oxidative stress and understand their significance in pediatric samples. Influence of oxidative stress on Celiac Disease was analysed by evaluating lipid peroxidation, reduced glutathione, Glutathione peroxidase, etc. A comparison was performed among <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients on gluten free diet (<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>), and healthy controls. Peripheral <jats:styled-content style=\"fixed-case\">nT<\/jats:styled-content>regs exhibited a similar pattern of reduced numbers in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> cases when compared to healthy controls. On the other hand, inducible Tregs were much lower in <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> patients as compared to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients. Expression of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2 on <jats:styled-content style=\"fixed-case\">iT<\/jats:styled-content>regs was elevated in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>, however, expression on <jats:styled-content style=\"fixed-case\">nT<\/jats:styled-content>regs was unaltered in all the three groups. The inflammatory cytokine <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 positive Treg cells were found to be elevated in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> as compared to control group. Oxidative stress was elevated in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> as compared to healthy controls while that in <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> samples was lower in comparison to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. The levels of <jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content>, activities of enzymes <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> and Catalase were higher in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> samples when compared to controls. However, enzyme Glutathione peroxidase and reduced glutathione levels declined in both <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> groups as compared to controls. This report highlights the effect of elevated oxidative stress in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> on reduced traffic of <jats:styled-content style=\"fixed-case\">iT<\/jats:styled-content>regs toward periphery. A strong correlation was observed between the cytokine <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2 expression in movement of <jats:styled-content style=\"fixed-case\">iT<\/jats:styled-content>regs in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/apm.12735","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T05:22:40Z","timestamp":1500873760000},"page":"888-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Regulatory T cell subsets in peripheral blood of celiac disease patients and TLR2 expression: correlation with oxidative stress"],"prefix":"10.1111","volume":"125","author":[{"given":"Sanjay","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biochemistry Panjab University Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhna","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Postgraduate Institute of Medical Education &amp; Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Panjab University Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.4.557"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.13612"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.05.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4040243"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b01155"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.4049\/jimmunol.162.9.5317","article-title":"Thymus and autoimmunity: production of CD25+ CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self\u2010tolerance","volume":"162","author":"Itoh M","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200320274"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.04.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0501-x"},{"key":"e_1_2_9_11_1","first-page":"7","article-title":"Changes in natural Foxp3(+)Treg but not mucosally\u2010imprinted CD62L(neg)CD38(+)Foxp3(+)Treg in the circulation of celiac disease patients","volume":"8","author":"Leeuwen MA","year":"2013","journal-title":"PLoS ONE"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2010.11.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03389.x"},{"key":"e_1_2_9_14_1","first-page":"17","article-title":"Toll\u2010like receptor 2 as a regulator of oral tolerance in the gastrointestinal tract","volume":"606383","author":"Tunis MC","year":"2014","journal-title":"Mediators Inflamm"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02783.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0001-37652012000100018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074129"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00173"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2004.05.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000870"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"e_1_2_9_22_1","first-page":"206","article-title":"Food additives and their mutagenic effect. 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