{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:12:52Z","timestamp":1761217972388},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102016R1D1A1A09919609"],"award-info":[{"award-number":["NRF\u20102016R1D1A1A09919609"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>The purpose of this study was to clarify the role of human beta defensin\u20101 (hBD\u20101) in predicting PAC in morphologically normal prostate glands. In total, 25 patients with a negative initial biopsy for PAC and diagnosed as PAC positive in subsequent biopsies performed within 1 year of the initial biopsy were included. As a control group, 22 patients negative for PAC in at least three consecutive histologic examinations were selected. Expression of hBD\u20101 was analyzed separately via immunohistochemistry in paired cores of non\u2010neoplastic gland and PAC in the false\u2010negative group and control group. Loss of hBD\u20101 expression was observed in 95.6% and 90.0% PAC cases with Gleason Patterns 3 and 4 in repeat biopsies, respectively. hBD\u20101 loss of basal cells in 40 (85.1%) previous non\u2010neoplastic biopsy cores in the false\u2010negative group was observed, in contrast to preserved basal cell expression of hBD\u20101 in 64 (72.7%) biopsy cores in the control group (p = 0.001). Multivariate logistic regression analysis showed that hBD\u20101 basal cell loss (\u226520% of prostatic glands in total cores) is an independent factor for predicting PAC (odds ratio: 4.739, confidence interval: 1.093\u201320.554, p = 0.038). hBD\u20101 loss of basal cells is a useful indicator to identify extremely high\u2010risk patients with initially negative biopsy.<\/jats:p>","DOI":"10.1111\/apm.12749","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T13:56:39Z","timestamp":1504878999000},"page":"1063-1069","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A role of human beta defensin\u20101 in predicting prostatic adenocarcinoma in cases of false\u2010negative biopsy"],"prefix":"10.1111","volume":"125","author":[{"given":"Soon Auck","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Pathology Soonchunhyang University Cheonan Hospital Cheonan 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