{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:35:34Z","timestamp":1767339334304,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"crossref","award":["VGHKS103-009","104-020"],"award-info":[{"award-number":["VGHKS103-009","104-020"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Institutional Review Board of Kaohsiung Veterans General Hospital","award":["VGHKS97-CT2-08, 2008"],"award-info":[{"award-number":["VGHKS97-CT2-08, 2008"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>To evaluate the clinicopathological characteristics, high\u2010risk lifestyle factors (<jats:styled-content style=\"fixed-case\">HRLF<\/jats:styled-content>: chronic exposure to sun, betel quid, alcohol, and tobacco), and prognostic factors of lip cancer. The hospital records of patients with pathologically confirmed lip squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>, n\u00a0=\u00a0112) and lip basal cell carcinoma (<jats:styled-content style=\"fixed-case\">LBCC<\/jats:styled-content>, n\u00a0=\u00a021) were reviewed. Differences in clinicopathological characteristics between <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LBCC<\/jats:styled-content>, upper and lower lip, and status of second primary tumors were compared by chi\u2010square test and logistic regression. The prognostic factors for <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> were analyzed by Cox regression. Compared with <jats:styled-content style=\"fixed-case\">LBCC<\/jats:styled-content> patients, <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> patients were men\u2010predominant (p\u00a0&lt;\u00a00.001), had younger ages at onset (p\u00a0&lt;\u00a00.001), and higher rates of lower lips involvement (p\u00a0&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">HRLF<\/jats:styled-content>s. Patients with second primary tumors were highly associated with lower lip cancer involvement (adjusted odds ratio\u00a0=\u00a02.91, p\u00a0=\u00a00.03). Patients with lower lip cancer had more <jats:styled-content style=\"fixed-case\">HRLF<\/jats:styled-content>s with an increasing linear trend (p\u00a0=\u00a00.004). The poorer prognostic factors of <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> for disease\u2010specific survival were advanced stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> [crude hazard ratio (<jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content>)\u00a0=\u00a011.16, p\u00a0&lt;\u00a00.001], tumor dimension\u00a0&gt;4\u00a0cm (<jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content>\u00a0=\u00a08.19, p\u00a0=\u00a00.006), lymph node involvement (<jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content>\u00a0=\u00a011.48, p\u00a0&lt;\u00a00.001), and recurrence (<jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content>\u00a0=\u00a03.96, p\u00a0=\u00a00.01); whereas for disease\u2010free survival were moderately to poorly differentiated <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content>\u00a0=\u00a04.97, p\u00a0=\u00a00.002) and alcohol consumption (<jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content>\u00a0=\u00a03.13, p\u00a0=\u00a00.04). <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> and lower lip cancer were highly associated with <jats:styled-content style=\"fixed-case\">HRLF<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/apm.12751","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T07:42:44Z","timestamp":1505461364000},"page":"1007-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinicopathological study of lip cancer: a retrospective hospital\u2010based study in Taiwan"],"prefix":"10.1111","volume":"125","author":[{"given":"Hui\u2010Wen","family":"Tseng","sequence":"first","affiliation":[{"name":"Department of Dermatology Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huei\u2010Han","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Wang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luo\u2010Ping","family":"Ger","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"},{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yow\u2010Ling","family":"Shiue","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70168-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70144-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.10.034"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1999.tb00300.x"},{"volume-title":"SEER Cancer Statistics Review, 1975\u20102010","year":"2013","author":"Howlader N","key":"e_1_2_8_7_1"},{"key":"e_1_2_8_8_1","first-page":"1543","article-title":"Lip cancer: a 10\u2010year retrospective epidemiological study","volume":"32","author":"Maruccia M","year":"2012","journal-title":"Anticancer Res"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487309139728"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198001000-00002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70050-1"},{"volume-title":"Head and Neck Cancer: a Multidisciplinary Approach","year":"2009","author":"Harrison LB","key":"e_1_2_8_12_1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.06.018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21088"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80457-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)30844-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(93)90006-T"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844318509074517"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80053-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00012093"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200301000-00008"},{"key":"e_1_2_8_22_1","first-page":"1433","article-title":"Lip cancer: a 16\u2010year retrospective epidemiological study in Eastern part of Turkey","volume":"66","author":"Bozan N","year":"2016","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.03.054"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.04.013"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12559"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12340"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199908)21:5<447::AID-HED11>3.0.CO;2-R"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.07.010"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1994.tb03199.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121159"},{"key":"e_1_2_8_31_1","unstructured":"Taiwan Cancer Registry.Taiwan Cancer Registry Annual Report. Available from:http:\/\/tcr.cph.ntu.edu.tw\/."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.03.009"},{"volume-title":"Environmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects","year":"1986","author":"National Research Council","key":"e_1_2_8_33_1"},{"key":"e_1_2_8_34_1","unstructured":"National Center for Health Statistics.Vital Statistics of the United States 1988 Volume II Mortality Part A Public Health Service 1991; II."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(98)80010-6"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.09.010"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.04.010"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.81"},{"key":"e_1_2_8_39_1","first-page":"2488","article-title":"Genetic progression model for head and neck cancer: implications for field cancerization","volume":"56","author":"Califano J","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_8_40_1","first-page":"2484","article-title":"Multiple head and neck tumors: evidence for a common clonal origin","volume":"56","author":"Bedi GC","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.08.007"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.12751","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T05:39:41Z","timestamp":1694324381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,15]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/apm.12751"],"URL":"https:\/\/doi.org\/10.1111\/apm.12751","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"type":"print","value":"0903-4641"},{"type":"electronic","value":"1600-0463"}],"subject":[],"published":{"date-parts":[[2017,9,15]]},"assertion":[{"value":"2017-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}