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During infection, eggs are deposited in the bladder causing an intense inflammatory reaction. Angiogenesis is defined as the formation of new blood vessels from preexisting ones and is recognized as a key event in cell proliferation and carcinogenesis and spread of malignant lesions. A growing amount of evidence points to angiogenesis playing a key role in schistosomiasis\u2010associated bladder cancer. Thus, identifying biomarkers of this process plays an important role in the study of cancer. Here, we review recent findings on the role of angiogenesis in bladder cancer and the growth factors that induce and assist in their development, particularly SCC of the bladder associated to urogenital schistosomiasis.<\/jats:p>","DOI":"10.1111\/apm.12756","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T16:13:21Z","timestamp":1506615201000},"page":"1056-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Angiogenesis in <i>Schistosoma haematobium<\/i>\u2010associated urinary bladder cancer"],"prefix":"10.1111","volume":"125","author":[{"given":"Anderson","family":"Dematei","sequence":"first","affiliation":[{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas Escola Superior de Sa\u00fade Instituto Polit\u00e9cnico do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00faben","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas Escola Superior de Sa\u00fade Instituto Polit\u00e9cnico do Porto Porto Portugal"},{"name":"I3S Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o da Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Soares","sequence":"additional","affiliation":[{"name":"I3S Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o da Universidade do Porto Porto Portugal"},{"name":"Departamento de Biomedicina Unidade de Bioqu\u00edmica Faculdade de Medicina Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Chronic Diseases INSA \u2013 National Institute of Health Dr. Ricardo Jorge Porto Portugal"},{"name":"Funda\u00e7\u00e3o Professor Ernesto Morais Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Richter","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine and International Health Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica C.","family":"Botelho","sequence":"additional","affiliation":[{"name":"I3S Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o da Universidade do Porto Porto Portugal"},{"name":"Department of Health Promotion and Chronic Diseases INSA \u2013 National Institute of Health Dr. Ricardo Jorge Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761989000500002"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization.Weekly epidemiological record 90th year 2015; 90 25\u201332.http:\/\/www.who.int\/wer"},{"key":"e_1_2_7_4_1","volume-title":"Schistosomiasis: Progress Report 2001\u20132011, Strategic Plan 2012\u20132020","author":"WHO","year":"2013"},{"key":"e_1_2_7_5_1","article-title":"Halting Schistosoma haematobium \u2010associated bladder cancer","author":"Botelho MC","journal-title":"Ira J Can Prev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70521-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.22.20821"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2012.10.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00029-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000430"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.63.133"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21731"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_7_15_1","first-page":"1","article-title":"Biological agents. 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