{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:59:47Z","timestamp":1781103587550,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Current diagnostic guidelines for celiac disease (CD<\/jats:styled-content>) in pediatric patients require a duodenal biopsy if the IgA anti\u2010tissue transglutaminase (tTG<\/jats:styled-content>) is below 10x the upper limit of normal (ULN<\/jats:styled-content>). Additional markers may enable a noninvasive diagnosis in this group. Serum intestinal\u2010fatty acid\u2010binding protein (I\u2010FABP<\/jats:styled-content>), a marker for intestinal epithelial damage, could be useful in this respect. A total of 95 children with a clinical suspicion of CD<\/jats:styled-content> and tTG<\/jats:styled-content> 1\u201010x ULN<\/jats:styled-content> were investigated. All had a duodenal biopsy and analysis of serum I\u2010FABP<\/jats:styled-content>. A control group of 161 children with familial short stature and normal tTG<\/jats:styled-content> was included. I\u2010FABP<\/jats:styled-content> levels in the 71 patients with tTG<\/jats:styled-content> 1\u201010x ULN<\/jats:styled-content> and biopsy\u2010proven CD<\/jats:styled-content> (median 725\u00a0pg\/mL) were not significantly different (p\u00a0=\u00a00.13) from the levels in the 24 patients with a tTG<\/jats:styled-content> 1\u201010x ULN<\/jats:styled-content> but a normal biopsy (median 497\u00a0pg\/mL). However, when combining tTG<\/jats:styled-content> and I\u2010FABP<\/jats:styled-content> levels, 11\/24 patients could have been diagnosed noninvasively if tTG<\/jats:styled-content> is \u2265 50 U\/mL and I\u2010FABP<\/jats:styled-content> \u2265880\u00a0pg\/mL or in 12\/19 patients if tTG<\/jats:styled-content> is \u2265 60 U\/mL and I\u2010FABP<\/jats:styled-content> \u2265 620\u00a0pg\/mL. Therefore, addition of I\u2010FABP<\/jats:styled-content> to the diagnostic procedure of CD<\/jats:styled-content> may provide a noninvasive diagnosis in patients with a tTG<\/jats:styled-content> \u2265 50 U\/mL.<\/jats:p>","DOI":"10.1111\/apm.12800","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T07:21:48Z","timestamp":1517383308000},"page":"186-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Serum intestinal fatty acid\u2013binding protein in the noninvasive diagnosis of celiac disease"],"prefix":"10.1111","volume":"126","author":[{"given":"Irene B.","family":"Oldenburger","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Wilhelmina Children's Hospital Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victorien M.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Wilhelmina Children's Hospital Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke","family":"Kardol\u2010Hoefnagel","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Immunology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick H. J.","family":"Houwen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Wilhelmina Children's Hospital Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henny G.","family":"Otten","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Immunology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i32.4399"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(03)00096-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"34371","DOI":"10.1038\/srep34371","article-title":"Accuracy of the serum intestinal fatty\u2010acid\u2010binding protein for diagnosis of acute intestinal ischemia: a meta\u2010analysis","volume":"29","author":"Sun DL","year":"2016","journal-title":"Sci Rep"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181d778c4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2014.140518"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0b013e3180644e32"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.627447"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31819194b0"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12194"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.006"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.035"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00205-09"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181ef8e50"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T18:44:07Z","timestamp":1695667447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/apm.12800"],"URL":"https:\/\/doi.org\/10.1111\/apm.12800","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]},"assertion":[{"value":"2017-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}