{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:30:45Z","timestamp":1773333045941,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Eosinophils are frequently encountered with squamous cell carcinomas (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) and it has been proposed that tumor\u2010associated tissue eosinophilia (<jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content>) could be of prognostic significance in oral <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>. The aim was to evaluate <jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content> in 83 oral cavity and 16 lip <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s as well as the best possible use of <jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content> as a prognostic marker. The number of eosinophils was counted per high power fields (<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>, \u00d7400) in three different representative areas of the tumor and its stroma. The degree of <jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content> was analyzed in relation to clinicopathological features of tumors and patients\u2019 survival (follow\u2010up mean 40.7\u00a0months) using Fisher's exact test. <jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content> was detected in 58 (70%) oral and 8 (50%) lip <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> samples. The median number of eosinophils between oral and lip <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> was different (p\u00a0=\u00a00.028) but <jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content> was similar per <jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content> (p\u00a0=\u00a00.085). Totally, 6% of lip and 21% of oral <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> patients died during the follow\u2010up. The patients with the higher <jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content> had significantly better survival than the patients with the lower <jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content> (p\u00a0=\u00a00.0136). The best cut\u2010off value predicting the survival was 4 eosinophils\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">TATE<\/jats:styled-content> is a prognostic marker for oral and lip <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>: more than 4 eosinophils\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content> may predict more favorable prognosis.<\/jats:p>","DOI":"10.1111\/apm.12809","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T06:15:30Z","timestamp":1519712130000},"page":"201-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Eosinophilia is a favorable prognostic marker for oral cavity and lip squamous cell carcinoma"],"prefix":"10.1111","volume":"126","author":[{"given":"Emma","family":"Peurala","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Oral Radiology Institute of Dentistry Faculty of Medicine University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirella","family":"Tuominen","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Radiology Institute of Dentistry Faculty of Medicine University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliisa","family":"L\u00f6yttyniemi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Radiology Institute of Dentistry Faculty of Medicine University of Turku Turku Finland"},{"name":"Department of Pathology Turku University Hospital Turku 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