{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:28:34Z","timestamp":1792603714873,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>The aim is to study IL\u201010 polymorphisms and IL\u201010 level and assess their relation to T\u2010cell subsets in childhood immune thrombocytopenia (ITP). In all, 40 (25 acute, 15 chronic) ITP child patients were investigated at time of presentation, compared to 15 healthy, age\u2010 and gender\u2010matched controls and followed up for 1\u00a0year to determine chronic cases. Studying the effect of IL\u201010 promoter polymorphism was done by PCR\u2010RFLP, IL\u201010 level was determined by ELISA, natural killer cells and T\u2010cell subsets were evaluated by flow cytometry. Subjects with IL\u201010 promoter (1082 AA and 592 AA) genotypes had lower IL\u201010 levels and had lower CD4%, higher CD8%, lower CD4\/CD8 ratio and lower T\u2010reg%. IL\u201010 polymorphisms had no effect on NK%. IL\u201010 serum levels and IL\u201010 promoter polymorphic genotype frequencies are not different between ITP cases and controls; however, in ITP patients, IL\u201010 promoter (1082 AA and 592 AA) genotypes and associated lower CD4, higher CD8, lower CD4\/CD8 ratio is associated with more severe thrombocytopenia at presentation and had a poorer response to first\u2010line treatment. Patients with lower T\u2010reg cells had a higher tendency to develop chronic ITP. IL\u201010 level and polymorphisms as well as disturbed T\u2010cell subsets percentages are demonstrable effectors of immune dysfunction in ITP and can affect the presentation and outcome of childhood ITP.<\/jats:p>","DOI":"10.1111\/apm.12823","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T05:05:21Z","timestamp":1524719121000},"page":"380-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["IL\u201010 polymorphisms and T\u2010cell subsets could affect the clinical presentation and outcome of childhood immune thrombocytopenia in Egyptian population"],"prefix":"10.1111","volume":"126","author":[{"given":"Mohamed A.","family":"Soliman","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology Faculty of Medicine Menoufia University Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed 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