{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:17Z","timestamp":1790697917243,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004571","name":"Minist\u00e8re des Affaires Sociales et de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009420","name":"Varsinais-Suomen Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009420","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Colistin resistance mediated by mobile <jats:italic>mcr\u20101<\/jats:italic> gene has raised concern during the last years. After steep increase in <jats:italic>mcr\u20101<\/jats:italic> reports, other <jats:italic>mcr<\/jats:italic>\u2010gene variants (<jats:italic>mcr\u20102<\/jats:italic> to <jats:italic>mcr\u20105<\/jats:italic>) have been revealed as well. In 2016, a clinical study was conducted on asymptomatic stool carriage of extended spectrum beta\u2010lactamase (<jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>) producing <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> among Finnish adults. All suspected <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content> producing bacterial isolates were first tested by phenotypic <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010confirmation methods, and then further analyzed with whole genome sequencing to identify the resistance genes. We found one study subject carrying a colistin resistant <jats:italic>E.\u00a0coli<\/jats:italic> with a transferrable <jats:italic>mcr\u20101<\/jats:italic> gene. This multi\u2010drug resistant isolate, although initially suspected to be an <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content> producer, did not carry any <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content> genes, but was proven to carry several other resistance genes by using whole genome sequencing. Sequence type was <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>93. The <jats:italic>mcr\u20101<\/jats:italic> gene was connected to IncX4 plasmid which suggests that the colistin resistance gene locates in the respective plasmid. Here, we report the finding of a <jats:italic>mcr\u20101<\/jats:italic> harboring human <jats:italic>E.\u00a0coli<\/jats:italic> isolate from Finland. Clinical antimicrobial resistance (<jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>) rates are low in Finland, and mobile colistin resistance has not been reported previously. This highlights the importance of <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> surveillance also in populations with low levels of resistance.<\/jats:p>","DOI":"10.1111\/apm.12834","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T05:05:21Z","timestamp":1524719121000},"page":"413-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The first human report of mobile colistin resistance gene, <i>mcr\u20101,<\/i> in Finland"],"prefix":"10.1111","volume":"126","author":[{"given":"Kirsi","family":"Gr\u00f6ndahl\u2010Yli\u2010Hannuksela","sequence":"first","affiliation":[{"name":"Institute of Biomedicine, Research Center for Cancer, Infections and Immunity University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Research Center for Cancer, Infections and Immunity University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu","family":"Kallonen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lindholm","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Expert Microbiology Unit Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Jalava","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Infectious Disease Control and Vaccinations Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisu","family":"Rantakokko\u2010Jalava","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Vuopio","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Research Center for Cancer, Infections and Immunity University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00424-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.06.023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2307.161638"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw335"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2015.20.49.30085"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.06.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2017.22.31.30588"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2017.22.31.30584"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2005.03.018"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv383"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.11.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-017-0186-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw328"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12720"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03850.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.11.116"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2204.151142"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.12.035"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:26:59Z","timestamp":1695547619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/apm.12834"],"URL":"https:\/\/doi.org\/10.1111\/apm.12834","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"assertion":[{"value":"2017-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}