{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:42:33Z","timestamp":1782895353574,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["TH96\/03"],"award-info":[{"award-number":["TH96\/03"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Immune thrombocytopenic purpura (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>) is an autoimmune bleeding disorder associated with platelet destruction. Abnormalities in frequency and function of different immune cells can play a crucial role in this disease. The aim of this study was to evaluate the prognostic value of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> markers\u2019 expressions by immune cells in <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>. Peripheral blood samples were collected from 25 <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> patients before and after treatment. The expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> markers was evaluated by flow cytometry technique. The expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56 was significantly lower before treatment than after it (p\u00a0=\u00a00.025 and p\u00a0=\u00a00.036, respectively). Furthermore, a positive correlation was found between <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38 expression with platelet count before (r\u00a0=\u00a00.496, p\u00a0=\u00a00.012) and after treatment (r\u00a0=\u00a00.404, p\u00a0=\u00a00.045). No significant relationship was found between this marker and platelet count while <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 expression was higher before treatment than after it (p\u00a0=\u00a00.002). In conclusion, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38 may have independent prognostic value in <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> and we suggest that it can be a prognostic marker for this disease.<\/jats:p>","DOI":"10.1111\/apm.12853","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T19:07:54Z","timestamp":1529521674000},"page":"523-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cellular expression of <scp>CD<\/scp> markers in immune thrombocytopenic purpura: implications for prognosis"],"prefix":"10.1111","volume":"126","author":[{"given":"Masumeh Maleki","family":"Behzad","sequence":"first","affiliation":[{"name":"Health Research Institute Research Center of Thalassemia &amp; Hemoglobinopathy Ahvaz Jundishapur University of Medical Sciences Ahvaz 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