{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:17:06Z","timestamp":1770513426759,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Previous studies indicated that single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) of genes coding for toll\u2010like receptors (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s) and toll\u2010interacting protein (<jats:styled-content style=\"fixed-case\">TOLLIP<\/jats:styled-content>) may be involved in the pathogenesis of pulmonary tuberculosis (<jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>). This study was designed to investigate potential associations between the polymorphisms in <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">TOLLIP<\/jats:styled-content><\/jats:italic> and susceptibility to latent tuberculosis infection (<jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content>) or subsequent <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> in a Chinese Han population. A total of 209 <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> and 201 <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> patients and 204 healthy control subjects (<jats:styled-content style=\"fixed-case\">HCS<\/jats:styled-content>) were enrolled in our study. We performed a logistic regression including sex and age as covariates to test the effect of genotype. Genotyping was conducted using the improved multiplex ligase detection reaction (<jats:styled-content style=\"fixed-case\">iMLDR<\/jats:styled-content>). Eleven markers in <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">TOLLIP<\/jats:styled-content><\/jats:italic> were assessed. No significant association between polymorphisms of <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4<\/jats:italic> with <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> was detected. For <jats:italic><jats:styled-content style=\"fixed-case\">TOLLIP<\/jats:styled-content><\/jats:italic>, rs5743899 (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.83, 95% CI: 1.20\u20132.80) <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotype were risk factors for <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> progression. Moreover, rs5743867 under addictive (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.54, 95% CI: 1.14\u20132.07) and recessive model (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.86, 95% CI: 1.22\u20132.83) were also risk factors for <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> susceptibility. Our results indicate that polymorphisms in <jats:italic><jats:styled-content style=\"fixed-case\">TOLLIP<\/jats:styled-content><\/jats:italic> affected the risk of <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> disease.<\/jats:p>","DOI":"10.1111\/apm.12855","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T19:07:54Z","timestamp":1529521674000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of <i><scp>TLR<\/scp>2<\/i>,<i><scp>TLR<\/scp>4<\/i>, and <i><scp>TOLLIP<\/scp><\/i> polymorphisms for their role in tuberculosis susceptibility"],"prefix":"10.1111","volume":"126","author":[{"given":"Shouquan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 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