{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T03:06:55Z","timestamp":1722222415921},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T00:00:00Z","timestamp":1532822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>The aim of this study was to test the hypothesis that <jats:italic>Staphylococcus epidermidis<\/jats:italic> isolated from prosthetic joint infections (PJIs) differs from <jats:italic>S.\u00a0epidermidis<\/jats:italic> isolated from normal flora in terms of its capacity to induce activation of caspase\u20101 and release of IL\u20101\u03b2 in human neutrophils. The amount of active caspase\u20101 was determined over 6\u00a0h by detecting Ac\u2010YVAD\u2010AMC fluorescence in human neutrophils incubated with <jats:italic>S.\u00a0epidermidis<\/jats:italic> isolates from PJIs (ST2) or normal flora. The amount of IL\u20101\u03b2 was detected by ELISA in neutrophil supernatants after 6\u00a0h of incubation. Mean IL\u20101\u03b2 release was lower after incubation with <jats:italic>S.\u00a0epidermidis<\/jats:italic> from PJIs compared to isolates from normal flora, but no statistically significant difference was found in active caspase\u20101. Substantial inter\u2010individual differences in both active caspase\u20101 and IL\u20101\u03b2 were noted. These results suggest that evasion of innate immune response, measured as reduced capacity to induce release of IL\u20101\u03b2 from human neutrophils, might be involved in the predominance of ST2 in <jats:italic>S.\u00a0epidermidis<\/jats:italic> PJIs, but that other microbe\u2010related factors are probably also important.<\/jats:p>","DOI":"10.1111\/apm.12861","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T01:16:05Z","timestamp":1532913365000},"page":"678-684","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Staphylococcus epidermidis<\/i> from prosthetic joint infections induces lower IL\u20101\u03b2 release from human neutrophils than isolates from normal flora"],"prefix":"10.1111","volume":"126","author":[{"given":"Emeli","family":"M\u00e5nsson","sequence":"first","affiliation":[{"name":"School of Medical Sciences Faculty of Medicine and Health \u00d6rebro University 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