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Rats were subjected to liver damage induced by intra\u2010peritoneal injection of thioacetamide (\n TAA<\/jats:styled-content>\n ).\n PA<\/jats:styled-content>\n was tested first for its acute toxicity and then administered by oral gavage at doses 5, 10, and 50 mg\/kg to rats. At the end of the 8\n th<\/jats:sup>\n week, livers from all rats were excised and evaluated\n ex vivo<\/jats:italic>\n . Measurements included alkaline phosphatase (\n AP<\/jats:styled-content>\n ), alanine transaminase (\n ALT<\/jats:styled-content>\n ), aspartate transaminase (\n AST<\/jats:styled-content>\n ) and gamma\u2010glutamyl transferase (\n GGT<\/jats:styled-content>\n ), serum platelet\u2010derived growth factor (\n PDGF<\/jats:styled-content>\n ) and transforming growth factor (\n TGF<\/jats:styled-content>\n \u2010\u03b21), and hepatic metalloproteinase enzyme (\n MMP<\/jats:styled-content>\n \u20102) and its inhibitor extracellular matrix protein (\n TIMP<\/jats:styled-content>\n \u20101). Oxidative stress was measured by liver malondialdehyde (\n MDA<\/jats:styled-content>\n ) and nitrotyrosine levels, urinary 8\u2010hydroxy 2\u2010 deoxyguanosine (8\u2010\n OH<\/jats:styled-content>\n \u2010\n dG<\/jats:styled-content>\n ), and hepatic antioxidant enzyme activities. The immunohistochemistry of\n TGF<\/jats:styled-content>\n \u2010\u03b2\n 1<\/jats:sub>\n was additionally performed.\n PA<\/jats:styled-content>\n revealed safe dose of 250 mg\/kg on experimental rats and positive effect on the liver. The results suggested reduced hepatic stellate cells (\n HSC<\/jats:styled-content>\n s) activity as verified from the attenuation of serum\n PDGF<\/jats:styled-content>\n and\n TGF<\/jats:styled-content>\n \u2010\u03b21, hepatic\n MMP<\/jats:styled-content>\n \u20102 and\n TIMP<\/jats:styled-content>\n \u20101, and oxidative stress. The extensive data altogether conclude that\n PA<\/jats:styled-content>\n treatment could protect the liver from the progression of cirrhosis through a possible mechanism inhibiting\n HSC<\/jats:styled-content>\n s activity.\n <\/jats:p>","DOI":"10.1111\/apm.12878","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T21:29:41Z","timestamp":1532899781000},"page":"710-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Hepatoprotectivity of Panduratin A against liver damage:\n In vivo<\/i>\n demonstration with a rat model of cirrhosis induced by thioacetamide"],"prefix":"10.1111","volume":"126","author":[{"given":"Suzy M.","family":"Salama","sequence":"first","affiliation":[{"name":"Department of Biomedical Science Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Abdel 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