{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:44:48Z","timestamp":1756572288847},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Intraductal carcinoma of the salivary glands is a rare, not well\u2010characterized tumor. We reviewed the literature and report the first case of a high\u2010grade unicystic intraductal carcinoma of the parotid. Formalin\u2010fixed\/paraffin\u2010embedded blocks were sectioned and stained for hematoxylin and eosin and immunostains (CAM5.2, EMA, CK5, p53, p63, SMA, S100 protein, DOG1, mammaglobin, AR, ER, PR, Her\u20102, and Ki67). A 72\u2010year\u2010old man showed a painless nodule (2\u00a0cm) in the right parotid region. A \u2018tumor of uncertain malignant potential\u2019 (low grade) was diagnosed by fine\u2010needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>). Preoperative magnetic resonance imaging revealed a well\u2010delimited, oval cyst without evidence of parenchymal invasion (T1\u2010scans: homogeneously isointense with hypointense thin peripheral ring; T2\u2010scans: strongly hyperintense). Histological examination confirmed a unilocular cyst lined by a multistratified epithelium arranged in solid, pseudopapillary, cribriform, and \u2018incomplete cribriform\/microcystic\u2019 patterns. Tumor cells were CAM5.2+, EMA+, mammaglobin+, AR+, p63+ (focal), CK5+ (focal), p53 (+, 20%), ER\u2010, PR\u2010, S100 protein\u2010, DOG1\u2010, and Her\u20102\u2010. A continuous peripheral layer of p63+\/CK5+\/SMA+ myoepithelial cells proved the \u2018<jats:italic>in\u00a0situ\u2019<\/jats:italic> nature of the tumor. The evidence of focal severe nuclear atypia, high mitotic index (12\u00a0mitoses\/10HPFs), and high proliferation index (40%) favored a high\u2010grade intraductal carcinoma. Preoperative <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> and clinic\u2013pathologic correlation are very helpful. Discrepancy in dysplasia grade between <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> and resected specimen can occasionally occur (especially in case of focal high\u2010grade features). Total sampling should exclude invasive areas or other cystic malignancies.<\/jats:p>","DOI":"10.1111\/apm.12882","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T11:08:15Z","timestamp":1535627295000},"page":"771-776","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Unicystic high\u2010grade intraductal carcinoma of the parotid gland: cytological and histological description with clinic\u2013pathologic review of the literature"],"prefix":"10.1111","volume":"126","author":[{"given":"Andrea","family":"Palicelli","sequence":"first","affiliation":[{"name":"Laboratory of Pathology Department of Translational Medicine UPO School of Medicine Novara Italy"},{"name":"Pathology Unit Arcispedale Santa Maria Nuova\u2010IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Pathology Unit \u201cAzienda Ospedaliera Nazionale S.S. Antonio e Biagio e Cesare Arrigo\u201d, Alessandria Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narciso","family":"Mariani","sequence":"additional","affiliation":[{"name":"Pathology Unit \u201cAzienda Ospedaliera Nazionale S.S. Antonio e Biagio e Cesare Arrigo\u201d, Alessandria Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Re","sequence":"additional","affiliation":[{"name":"Pathology Unit \u201cAzienda Ospedaliera Nazionale S.S. Antonio e Biagio e Cesare Arrigo\u201d, Alessandria Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Galla","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Department of Head and Neck and Locomotor Apparatus \u201cAzienda Ospedaliera Nazionale S.S. Antonio e Biagio e Cesare Arrigo\u201d Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Department of Head and Neck and Locomotor Apparatus \u201cAzienda Ospedaliera Nazionale S.S. Antonio e Biagio e Cesare Arrigo\u201d Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Pathology Unit \u201cInfermi\u201d Hospital Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunzio","family":"Salfi","sequence":"additional","affiliation":[{"name":"Pathology Unit \u201cS.Orsola\u2010Malpighi\u201d Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Valente","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Department of Translational Medicine UPO School of Medicine Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"WHO Classification of Head and Neck Tumors","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03135.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.64"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920201)69:3<609::AID-CNCR2820690302>3.0.CO;2-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510009397X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000128662.66321.be"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200402000-00017"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3528"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23411"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2013.47.6.592"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23770"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21405"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200608000-00013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001306"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896910367649"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000320"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:29:02Z","timestamp":1695043742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/apm.12882"],"URL":"https:\/\/doi.org\/10.1111\/apm.12882","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]},"assertion":[{"value":"2017-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}