{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:09:43Z","timestamp":1763226583388},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Candy Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>The aim of this study was to describe the epidemiology, symptomatology, pathology, genetics, and treatment of primary and metastatic small intestine melanoma in a national Danish cohort. All Danish patients diagnosed with small intestinal melanoma during the period 1980\u20132014 were included. For each patient, clinical data along with available pathology report and tissue was registered. Targeted next\u2010generation sequencing (<jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>) of known hotspots in 50 oncogenic genes was performed. Twenty patients with small intestinal melanoma were retrieved. Eight of these were primary melanomas. The median age was 66\u00a0years for primary melanoma patients and 58\u00a0years for secondary melanoma patients. The male\/female ratio (M\/F) was 3:1 for primary melanoma and 1:1 for secondary melanoma. The median time of survival was 3.5\u00a0months and 9\u00a0months for primary and secondary melanoma patients, respectively. <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content> of primary tumours showed polymorphisms in the <jats:italic><jats:styled-content style=\"fixed-case\">HRAS<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">KCA<\/jats:styled-content><\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>3<\/jats:italic> genes. Primary mucosal melanoma of the small intestines is a very rare disease, with an incidence of 0.04 cases\/million\/year in Denmark. Patients aged 59\u201370\u00a0years with abdominal symptoms should make the clinician consider a small bowel melanoma as a differential diagnosis. The prognosis ranged from less than a month to 183.6\u00a0months.<\/jats:p>","DOI":"10.1111\/apm.12883","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T11:08:15Z","timestamp":1535627295000},"page":"739-745","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Primary and secondary mucosal melanoma of the small intestine \u2013 a clinical, pathological, and genetic nationwide survey of Danish patients between 1980 and 2014"],"prefix":"10.1111","volume":"126","author":[{"given":"Jakob Koefoed","family":"Tingsgaard","sequence":"first","affiliation":[{"name":"Department of Pathology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalie","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauge Hjorth","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet Copenhagen Denmark"},{"name":"Department of Ophthalmology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nille","family":"Behrendt","sequence":"additional","affiliation":[{"name":"Department of Pathology Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linea Cecilie","family":"Melchior","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Bo","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Heegaard","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet Copenhagen Denmark"},{"name":"Department of Ophthalmology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70036-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12529"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21831"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0417-3"},{"key":"e_1_2_8_7_1","first-page":"739","article-title":"Primary mucosal melanomas a comprehensive review","volume":"5","author":"Marija M","year":"2012","journal-title":"J Clin Exp Pathol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90171-X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2007.apm_855.xml.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6713"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.73"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.016667"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.047"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.143"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01604.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.166.4.8610555"},{"key":"e_1_2_8_17_1","first-page":"677","article-title":"Malignant tumours of the small intestine: a review of histopathology, multidetector CT and MRI aspects","volume":"2011","author":"Anzidei M","journal-title":"Br J Radiol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2016.49.1.21"},{"key":"e_1_2_8_19_1","first-page":"694","article-title":"Capsule endoscopy for management of small bowel melanoma\u2010is it time yet?","volume":"8","author":"Prakoso E","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22539-5_13"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-999-0336-5"},{"key":"e_1_2_8_22_1","first-page":"1","article-title":"Checkpoint inhibition for advanced mucosal melanoma","volume":"27","author":"Thierauf J","year":"2017","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.031"},{"key":"e_1_2_8_24_1","first-page":"1","article-title":"Whole\u2010exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma","volume":"00","author":"Hintzsche J","year":"2016","journal-title":"Pigment Cell Melanoma Res"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.03.042"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0026893315060163"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071441"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.659"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:28:31Z","timestamp":1695043711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/apm.12883"],"URL":"https:\/\/doi.org\/10.1111\/apm.12883","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]},"assertion":[{"value":"2018-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}