{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:54:38Z","timestamp":1767851678554,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007132","name":"Otsuka Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005612","name":"Shionogi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) and autotaxin (<jats:styled-content style=\"fixed-case\">ATX<\/jats:styled-content>) play important roles in embryonic vasculogenesis and cancer progression. This study examines whether these two angiogenic factors cooperate in the mechanism that regulates vascular development during the progression of chronic viral hepatitis C (<jats:styled-content style=\"fixed-case\">CVH<\/jats:styled-content>\u2010C) (Inuyama classification, F1\u2013F4). First, surgical wedge biopsy specimens and needle biopsy specimens were obtained. Immunohistochemical staining for <jats:styled-content style=\"fixed-case\">ATX<\/jats:styled-content> and vascular endothelial growth factor receptor was assessed in serial sections. Immunoelectron microscopy was conducted with a perfusion\u2010fixation method. In normal control liver tissue specimens, <jats:styled-content style=\"fixed-case\">ATX<\/jats:styled-content> was expressed at low levels within the branches of the hepatic artery and hepatic sinusoids. In F1 <jats:styled-content style=\"fixed-case\">CVH<\/jats:styled-content>\u2010C liver tissue specimens, <jats:styled-content style=\"fixed-case\">ATX<\/jats:styled-content> was expressed within the branches of the hepatic artery. Additionally, <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\u20102 was expressed within the branches of the hepatic artery and capillaries. In F3\u2013F4 <jats:styled-content style=\"fixed-case\">CVH<\/jats:styled-content>\u2010C liver tissue specimens, positive staining for <jats:styled-content style=\"fixed-case\">ATX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\u20102 or <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\u20103 was detected in the branches of the hepatic artery or microlymphatic vessels. <jats:styled-content style=\"fixed-case\">ATX<\/jats:styled-content>\u20101 reaction products were specifically expressed on the plasma membrane of some microvascular endothelial cells (<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>s) in the proliferative capillary artery. <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\u20102 was expressed on caveolae in <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>s and vascular smooth muscle cells. <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\u20103 immunogold particles were also observed in lymphatic <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>s. These results suggest functional interactions among <jats:styled-content style=\"fixed-case\">ATX<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VEGFR<\/jats:styled-content>\u20102, and <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\u20103 in the modulation of hemovascular and lymphovascular cell activation during vascular development.<\/jats:p>","DOI":"10.1111\/apm.12904","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T04:36:03Z","timestamp":1542688563000},"page":"913-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Autotaxin and vascular endothelial growth factor receptor\u20102 and \u20103 are related to vascular development during the progression of chronic viral hepatitis C"],"prefix":"10.1111","volume":"126","author":[{"given":"Hiroaki","family":"Yokomori","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kitasato University Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy Kitasato University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Medical Education Center School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Bioscience Division Reagent Development Department AIA Research Group Tosoh Corp. Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Oda","sequence":"additional","affiliation":[{"name":"Organized Center of Clinical Medicine International University of Health and Welfare Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20193"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02369.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2009.06.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i3.377"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/S0021-9258(18)45911-X","article-title":"Identification, purification, and partial sequence analysis of autotaxin, a novel motility stimulating protein","volume":"267","author":"Stracke ML","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2006.00924.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412585200"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02419-05"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6412-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-09-0288"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4346(96)00325-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2015.03.009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1230"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.04.093"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02610.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.04.029"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-131"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5926-1-1"},{"key":"e_1_2_8_22_1","first-page":"11","article-title":"Regulatory mechanisms of hepatic microcirculatory hemodynamics: hepatic arterial system","volume":"34","author":"Oda M","year":"2006","journal-title":"Clin Hemorheol Microcirc"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.052"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00695054"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22849"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0952-1"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12904","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12904","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.12904","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T17:47:50Z","timestamp":1694368070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,19]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/apm.12904"],"URL":"https:\/\/doi.org\/10.1111\/apm.12904","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,19]]},"assertion":[{"value":"2018-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}