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The aim of this study was to compare the level of IgG antibodies to a specific epitope (P1 peptide) of human heat shock protein (Hsp)60 homologous to Hp Hsp60 (HspB) in the sera of healthy donors (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>), patients with Hp\u2010related gastritis or coronary heart disease (<jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>), uninfected or with Hp infection confirmed by rapid urease test, histological examination (dyspeptic patients) the <jats:sup>13<\/jats:sup>C urea breath test (<jats:sup>13<\/jats:sup>C <jats:styled-content style=\"fixed-case\">UBT<\/jats:styled-content>), and anti\u2010Hp antibodies (healthy donors, <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> patients). The Anti\u2010P1 IgG induction by Hp was verified by adsorption of sera with these bacteria and by experimental immunization of <jats:italic>Caviae porcellus<\/jats:italic> with Hp. Cytokine secretion by <jats:styled-content style=\"fixed-case\">THP<\/jats:styled-content>\u20101Blue\u2122 monocytes in response to P1 was also assessed. Anti\u2010P1 antibodies were detected in patients with gastritis or <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> infected with Hp and they were not found in uninfected individuals or asymptomatic carriers. No antibodies were raised against P2 in any group. Reduced cross\u2010reactivity to P1 was exhibited by sera adsorbed with Hp. <jats:italic>Caviae porcellus<\/jats:italic> infected with Hp produced anti\u2010P1 autoantibodies. <jats:styled-content style=\"fixed-case\">THP<\/jats:styled-content>\u20101<jats:styled-content style=\"fixed-case\">XB<\/jats:styled-content>lue\u2122 monocytes responded to P1 by production of proinflammatory cytokines. Autoantibodies against P1 in Hp\u2010positive patients with gastritis or <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> and upregulation of proinflammatory cytokines by P1 may contribute to the pathogenesis of Hp infection.<\/jats:p>","DOI":"10.1111\/apm.12925","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T05:12:43Z","timestamp":1549948363000},"page":"139-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Autoantibodies to a specific peptide epitope of human Hsp60 (<scp>ATVLA<\/scp>) with homology to <i>Helicobacter pylori<\/i> HspB in <i>H.\u00a0pylori<\/i>\u2010infected patients"],"prefix":"10.1111","volume":"127","author":[{"given":"Weronika","family":"Gonciarz","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Biology Institute of Microbiology, Biotechnology and Immunology Faculty of Biology and Environmental 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