{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:16:22Z","timestamp":1784081782661,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Antimicrobial resistance (<jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>) in <jats:italic>Neisseria gonorrhoeae<\/jats:italic> is a major public health concern globally. However, recent gonococcal <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> data from Eastern Europe are extremely limited and no <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> data for strains spreading in Ukraine have ever been internationally published. We investigated the <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> of <jats:italic>N.\u00a0gonorrhoeae<\/jats:italic> isolates in two regions of Ukraine (Ternopil 2013\u20132018, Dnipropetrovsk 2013\u20132014), and, where information was available, the treatment administered to the corresponding gonorrhoea patients. Determination of minimum inhibitory concentration (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>) of eight antimicrobials was performed using Etest and resistance breakpoints from the European Committee on Antimicrobial Susceptibility Testing (<jats:styled-content style=\"fixed-case\">EUCAST<\/jats:styled-content>) were applied. Overall, 9.3% of the examined 150 isolates were resistant to ciprofloxacin, 6.0% to tetracycline, 2.0% to azithromycin, and 0.7% to benzylpenicillin. No isolates were resistant to ceftriaxone, cefixime, spectinomycin, or gentamicin. However, one (0.7%) isolate showed a <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> value of 0.125\u00a0mg\/L for both ceftriaxone and cefixime, i.e., bordering resistance. Eighty\u2010eight (67.2%) of 131 patients were administered dual therapy (ceftriaxone 1\u00a0g plus doxycycline\/clarithromycin\/azithromycin\/ofloxacin) and 22 (16.8%) ceftriaxone 1\u00a0g monotherapy. Worryingly, 21 (16.0%) patients received monotherapy with clarithromycin\/doxycycline\/azithromycin\/ofloxacin\/benzylpenicillin. In conclusion, the antimicrobial susceptibility of gonococcal strains spreading in Ternopil and Dnipropetrovsk, Ukraine during 2013\u20132018 was high. Low levels of resistance to ciprofloxacin, tetracycline, azithromycin, and benzylpenicillin were found, but no resistance to the internationally recommended ceftriaxone, cefixime, or spectinomycin. Ceftriaxone 1\u00a0g should remain as empiric first\u2010line treatment, in dual therapy with azithromycin or doxycycline or in monotherapy. Continued and expanded gonococcal <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> surveillance in Ukraine is essential to monitor the susceptibility to particularly extended\u2010spectrum cephalosporins, azithromycin and doxycycline.<\/jats:p>","DOI":"10.1111\/apm.12948","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T13:49:20Z","timestamp":1553348960000},"page":"503-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antimicrobial susceptibility of <i>Neisseria gonorrhoeae<\/i> isolates and treatment of gonorrhoea patients in Ternopil and Dnipropetrovsk regions of Ukraine, 2013\u20132018"],"prefix":"10.1111","volume":"127","author":[{"given":"Iryna","family":"Boiko","sequence":"first","affiliation":[{"name":"WHO Collaborating Centre for Gonorrhoea and other STIs National Reference Laboratory for STIs Department of Laboratory Medicine Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"Clinical Laboratory Department Ternopil Regional Clinical Dermatovenerologic Dispensary Ternopil Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Golparian","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Gonorrhoea and other STIs National Reference Laboratory for STIs Department of Laboratory Medicine Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Krynytska","sequence":"additional","affiliation":[{"name":"Department of Functional and Laboratory Diagnostics I. 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