{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:22:22Z","timestamp":1780878142057,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>The aim of this study was to examine the changes in hemostasis parameters in endocarditis and thromboembolic events in nonfatal methicillin\u2010sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> bacteremia (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SAB<\/jats:styled-content>) \u2013 a topic not evaluated previously. In total, 155 patients were recruited and were categorized according to the presence of endocarditis or thromboembolic events with gender\u2010age adjusted controls. Patients who deceased within 90\u00a0days or patients not chosen as controls were excluded. <jats:styled-content style=\"fixed-case\">SAB<\/jats:styled-content> management was supervised by an infectious disease specialist. Patients with endocarditis (N\u00a0=\u00a021), compared to controls (N\u00a0=\u00a021), presented lower antithrombin <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> at day 4 (p\u00a0&lt;\u00a00.05), elevated antithrombin <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> at day 90 (p\u00a0&lt;\u00a00.01), prolonged activated partial thromboplastin time at days 4 and 10 (p\u00a0&lt;\u00a00.05), and enhanced thrombin\u2013antithrombin complex at day 4 (p\u00a0&lt;\u00a00.01). Thromboembolic events (N\u00a0=\u00a08), compared to controls (N\u00a0=\u00a034), significantly increased thrombin\u2013antithrombin complex at day 4 (p\u00a0&lt;\u00a00.05). In receiver operating characteristic analysis, the changes in these hemostasis parameters at day 4 predicted endocarditis and thromboembolic events (p\u00a0&lt;\u00a00.05). No differences in hemoglobin, thrombocyte, prothrombin fragment, thrombin time, factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>, D\u2010dimer or fibrinogen levels were observed between cases and controls. The results suggest that nonfatal <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SAB<\/jats:styled-content> patients present marginal hemostasis parameter changes that, however, may have predictability for endocarditis or thromboembolic events. Larger studies are needed to further assess the connection of hemostasis to complications in <jats:styled-content style=\"fixed-case\">SAB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/apm.12955","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T14:04:20Z","timestamp":1555941860000},"page":"515-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in hemostasis parameters in nonfatal methicillin\u2010sensitive <i>Staphylococcus aureus<\/i> bacteremia complicated by endocarditis or thromboembolic events: a prospective gender\u2010age adjusted cohort study"],"prefix":"10.1111","volume":"127","author":[{"given":"Erik","family":"Forsblom","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Inflammation Center University of Helsinki and Helsinki University Hospital Helsinki 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