{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:28:47Z","timestamp":1790792927066,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Intraductal carcinomas (IDCs) are rare, not well\u2010characterized salivary gland tumors. A systematic literature review of pure IDCs (without stromal invasion) of low\u2010grade (LG\u2010IDCs) or high\u2010grade (HG\u2010IDCs) was performed: IDCs were classified using the apocrine (AR+\/S100\u2212) vs intercalated (S100+\/AR\u2212) classification. Eighty\u2010two LG\u2010IDCs and 11 HG\u2010IDCs were identified (84% parotid; 11% oral; 3% submandibular; 1% lacrimal; and 1% unknown). Out of 11 HG\u2010IDCs, 2 HG\u2010IDCs (18%) recurred as HG\u2010IDC or invasive carcinoma. IDCs were classified as follows: intercalated (30%); mixed apocrine and intercalated (27%); apocrine (11%); oncocytic (6%); intercalated with focal oncocytic features (1%); and unclassifiable (25%). Double AR\/S100 expressors (4%) or discrepancies between morphology and immunophenotype (9%) were found. Apocrine features and necrosis were more frequent in HG\u2010IDCs (55%; 45%). Pleomorphism favored HG\u2010IDCs (especially when combined with &gt;10\u00a0mitoses\/10 HPFs and\/or Ki67 index &gt;10%), being associated with apocrine areas at least in 3 HG\u2010IDCs (27%). IDCs were typically mammaglobin+\/ER\u2010\/PR\u2010\/DOG1\u2010. No immunomarker clearly distinguished HG\u2010IDCs from LG\u2010IDCs. About 57% IDCs (16 LG\u2010IDCs, 1 HG\u2010IDC) showed <jats:italic>RET<\/jats:italic> rearrangements, including <jats:italic>NCOA4\u2010RET<\/jats:italic> (eight intercalated and two unclassifiable IDCs) and <jats:italic>TRIM27\u2010RET<\/jats:italic> fusions (two mixed IDCs). No <jats:italic>ETV6<\/jats:italic>, <jats:italic>ALK\u20101<\/jats:italic>, <jats:italic>ROS<\/jats:italic>, <jats:italic>NTRK3<\/jats:italic>, <jats:italic>MAML2<\/jats:italic>, <jats:italic>MAML3,<\/jats:italic> or <jats:italic>PLAG1<\/jats:italic> rearrangements were identified. Complete excision and total sampling should exclude invasive areas.<\/jats:p>","DOI":"10.1111\/apm.13009","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T21:51:51Z","timestamp":1573163511000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases"],"prefix":"10.1111","volume":"128","author":[{"given":"Andrea","family":"Palicelli","sequence":"first","affiliation":[{"name":"Pathology Unit Azienda Unit\u00e0 Sanitaria Locale\u2010IRCCS Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"WHO Classification of Head and Neck Tumors","author":"El\u2010Naggar 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