{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:29:40Z","timestamp":1790267380832,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Burkitt lymphoma (BL) is an aggressive non\u2010Hodgkin lymphoma. The prevalence of BL is ten\u2010fold higher in areas with stable transmission of <jats:italic>Plasmodium falciparum<\/jats:italic> malaria, where it is the most common childhood cancer, and is referred to as endemic BL (eBL). In addition to its association with exposure to <jats:italic>P.\u00a0falciparum<\/jats:italic> infection, eBL is strongly associated with Epstein\u2013Barr virus (EBV) infection (&gt;90%). This is in contrast to BL as it occurs outside <jats:italic>P.\u00a0falciparum<\/jats:italic>\u2010endemic areas (sporadic BL), where only a minority of the tumours are EBV\u2010positive. Although the striking geographical overlap in the distribution of eBL and <jats:italic>P.\u00a0falciparum<\/jats:italic> was noted shortly after the first detailed description of eBL in 1958, the molecular details of the interaction between malaria and eBL remain unresolved. It is furthermore unexplained why exposure to <jats:italic>P.\u00a0falciparum<\/jats:italic> appears to be essentially a prerequisite to the development of eBL, whereas other types of malaria parasites that infect humans have no impact. In this brief review, we summarize how malaria exposure may precipitate the malignant transformation of a B\u2010cell clone that leads to eBL, and propose an explanation for why <jats:italic>P.\u00a0falciparum<\/jats:italic> uniquely has this capacity.<\/jats:p>","DOI":"10.1111\/apm.13018","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T05:05:15Z","timestamp":1583384715000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Endemic Burkitt lymphoma \u2013 an aggressive childhood cancer linked to <i>Plasmodium falciparum<\/i> exposure, but not to exposure to other malaria parasites"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-3324","authenticated-orcid":false,"given":"Maria del Pilar","family":"Quintana","sequence":"first","affiliation":[{"name":"Centre for Medical Parasitology at Department of Immunology and 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