{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:35:27Z","timestamp":1782398127897,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Despite the interest of researchers in IgG4\u2010related disease (IgG4\u2010RD), many questions still remain unanswered regarding the thyroid gland. We aimed to clarify the relationship between IgG4\u2010positive plasma cells and the histopathological pattern in the Hashimoto thyroiditis (HT) in a Finnish series. HT specimens (n\u00a0=\u00a0280) were retrieved from the Department of Pathology, Fimlab Laboratories. After re\u2010evaluation, 82 (29%) cases (72 females and 10 males, 52\u00a0\u00b1\u00a017\u00a0years) with significant fibrosis were selected. CD38, IgG and IgG4 positivity in plasma cells was evaluated by immunohistochemistry. Adjusted IgG4\u2010positive plasma cells per HPF\u00a0&gt;\u00a020 and IgG4\u2010 to IgG\u2010positive plasma cell ratio\u00a0&gt;\u00a030% were adopted as threshold criteria and related to other morphological features. IgG4\u2010positive HT group included 13 cases (15% from fibrotic HT, 4.6% from all HT, 50\u00a0\u00b1\u00a015\u00a0years, 11 females) with adjusted HPF count 30\u00a0\u00b1\u00a05 (23\u201340) IgG4\u2010positive cells. IgG4\u2010positivity significantly correlated with the presence of lobulation, oncocytic metaplasia and certain type of fibrosis, fibrosis spread outside the gland, lymphocytes\/plasma cells epithelial penetration, the predominance of microfollicles and follicular atrophy in the present study. Despite the persisting uncertainty whether HT is IgG4\u2010RD, HT with IgG4\u2010positive plasma cells is histopathologically distinct entity with some geographic variability.<\/jats:p>","DOI":"10.1111\/apm.13067","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T05:51:08Z","timestamp":1592977868000},"page":"531-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["IgG4\u2010positive plasma cells in Hashimoto thyroiditis: IgG4\u2010related disease or inflammation\u2010related IgG4\u2010positivity?"],"prefix":"10.1111","volume":"128","author":[{"given":"Jarkko","family":"Lintusaari","sequence":"first","affiliation":[{"name":"Pathology Fimlab Laboratories Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eini","family":"Vesaniemi","sequence":"additional","affiliation":[{"name":"Pathology Fimlab Laboratories Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kalfert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery First Faculty of Medicine University Hospital Motol Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ilvesaro","sequence":"additional","affiliation":[{"name":"Pathology Fimlab Laboratories Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Ludv\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kholov\u00e1","sequence":"additional","affiliation":[{"name":"Pathology Fimlab Laboratories Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"219","article-title":"Zur Kenntnis der lymphomat\u00f6sen Ver\u00e4nderung der Schilddr\u00fcse (struma lymphomatosa)","volume":"97","author":"Hashimoto H","year":"1912","journal-title":"Arch f\u00fcr Klin Chir"},{"key":"e_1_2_5_3_1","first-page":"60","volume-title":"Diagnostic pathology and molecular genetics of the thyroid: a comprehensive guide for practicing thyroid pathology","author":"Nikiforov YE","year":"2018"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(74)80063-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12845"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34593"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201510-703BC"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.05.023"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200932"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0847-1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2012.02.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.085613"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283413469"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-1024"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20215"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0404"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02419.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1794"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.68"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0063"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200485"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9368-5"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1893-6"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.285606"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1397-1"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0211"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319873"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214603"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2016.07.003"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12297"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13787"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-015-0620-6"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3783"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2014.08.006"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200402"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.13067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.13067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:39:26Z","timestamp":1693910366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/apm.13067"],"URL":"https:\/\/doi.org\/10.1111\/apm.13067","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,6]]},"assertion":[{"value":"2020-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}