{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:58:57Z","timestamp":1790175537680,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Surgeons, who documented what they had seen and felt in the abdomen of the patient, made the earliest descriptions of Crohn\u2019s disease (CD). Dalziel wrote the first pathology description in 1913. Crohn and his coworkers reinvented what Dalziel had written about and called it by a different name, \u2018regional enteritis\u2019. Later others elaborated on the histologic features, at first the lymphoid follicles, later the granulomas. Some thought the latter were comprised of lymphatic endothelial cells and that endothelial plugs obstructed the lymphatics. Tonelli and others recognized that lymphedema was important and caused by obstructions to lymphatic vasculature. Some lymphatics they described contained lymphocyte plugs and others granulomas. Immunohistochemistry (IHC) has now shown that endothelial cells are not the cause of lymphatic obstruction, but rather CD68\u2010positive macrophages, concluding that the \u2018lymphocyte thrombi\u2019 are passive, caught upstream of granuloma\u2010obstructed lymphatics. Numerous authors recognized that transmural edema was the most significant change in Crohn\u2019s disease and that this was later followed by fibrosis and contracture of the diseased segment. Key descriptive papers spoke of the segmental lymphedema. Most recently, attention has been given to attachments of the intralymphatic CD68+ granulomas to a focal point where endothelial damage occurred, damage suggesting infectious penetration of the mucosa, necrosis of lymphatic endothelium and then granulomatous response, both inside and outside the lymphatics, of submucosa, muscularis, and subserosa. D2\u201040 IHC outlines the endothelium, and anti\u2010CD68 shows the granulomas. IHC adds a valuable perspective when reviewing CD resections.<\/jats:p>","DOI":"10.1111\/apm.13081","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T20:29:02Z","timestamp":1600720142000},"page":"621-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["What the early pathologists got wrong, and right, about the pathology of Crohn\u2019s disease: a historical perspective"],"prefix":"10.1111","volume":"128","author":[{"given":"Herbert J.","family":"Van Kruiningen","sequence":"first","affiliation":[{"name":"Department of Pathobiology University of Connecticut Storrs CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v7.i2.175"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70270-X"},{"key":"e_1_2_3_4_1","first-page":"212","article-title":"An Immunohistochemical search for infectious agents in Crohn's disease","volume":"6","author":"Cartun R","year":"1993","journal-title":"Mod Pathol"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.03.021"},{"key":"e_1_2_3_6_1","first-page":"16","article-title":"A singular case of stricture and thickening of ileum","volume":"4","author":"Combe C","year":"1813","journal-title":"Med Tran of Roy Coll Physicians London"},{"key":"e_1_2_3_7_1","volume-title":"Clinical lectures on some obscure diseases of the abdomen","author":"Fenwick S","year":"1889"},{"key":"e_1_2_3_8_1","first-page":"1068","article-title":"Chronic intestinal enteritis","volume":"2","author":"Dalziel T","year":"1913","journal-title":"BMJ"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1932.02740680019005"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)62866-0"},{"key":"e_1_2_3_11_1","first-page":"181","article-title":"Regional ileitis","volume":"72","author":"Blackburn G","year":"1939","journal-title":"St Bartholomew's Hosp Rep"},{"key":"e_1_2_3_12_1","first-page":"475","article-title":"Cicatrizing enteritis (regional ileitis) as a pathologic entity: analysis of one hundred and twenty cases","volume":"24","author":"Warren S","year":"1948","journal-title":"Am J Pathol"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1954.02940370001001"},{"key":"e_1_2_3_14_1","unstructured":"Van PatterWN.Pathology and pathogenesis of regional enteritis. PhD Dissertation University of Minnesota Minneapolis 1952."},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(54)80024-2"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.4.335"},{"key":"e_1_2_3_17_1","volume-title":"Il Linfedema dell'Intestino (malattia di crohn)","author":"Tonelli P","year":"2001"},{"key":"e_1_2_3_18_1","first-page":"15","volume-title":"Regional Enteritis (Crohn's Disease) Skandia International Symposia","author":"Morson B","year":"1971"},{"key":"e_1_2_3_19_1","volume-title":"Histopathologic spectrum of regional enteritis and ulcerative colitis","author":"Mottet NK","year":"1971"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04605.x"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12268"},{"key":"e_1_2_3_22_1","first-page":"454","article-title":"Ano\u2010genital granulomatosis and Crohn's disease: a case series of males presenting with genital lymphoedema","volume":"11","author":"Alexakis C","year":"2017","journal-title":"J Crohn's Colitis"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2012.00923.x"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000831"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.13081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:16:24Z","timestamp":1693876584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,4]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/apm.13081"],"URL":"https:\/\/doi.org\/10.1111\/apm.13081","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,4]]},"assertion":[{"value":"2020-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}