{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T15:11:40Z","timestamp":1723043500183},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Programmed cell death protein 1 (PD\u20101) is an immune checkpoint receptor which plays an important role in a patient's immune responses to microbial and cancer antigens. It is expressed in tumor\u2010infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD\u20101 expression and its prognostic value in tongue cancer. The data of tongue squamous cell carcinoma (TSCC) patients (N\u00a0=\u00a081) treated in Tampere University Hospital between 1999 and 2013 were used. Control data consisted of patients with non\u2010malignant tongue mucous membrane lesions (N\u00a0=\u00a048). The formalin\u2010fixed paraffin\u2010embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD\u20101 was examined semi\u2010quantitatively. The density and intensity of PD\u20101\u00a0+\u00a0cells were significantly higher in TSCC than in control samples. The expression of PD\u20101 correlated with better survival. The expression of PD\u20101 could be a potential prognostic marker in TSCC. 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