{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:29:58Z","timestamp":1781641798124,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Extramammary Paget\u2019s disease (EMPD) is a rare malignant skin neoplasm characterized by intraepidermal proliferation of tumor cells. The tumor cells of EMPD may sometimes invade into the dermis or metastasize into the regional lymph nodes. Several studies have proposed mechanisms underlying the increased invasiveness of EMPD; however, molecular markers indicating invasiveness have yet to be well characterized. Laminin\u20105 (Lam\u20105), a heterotrimer composed of three chains (\u03b13, \u03b23, and \u03b32), is a major component of the basement membrane in many tissues. One of the chains, Lam\u20105 \u03b32, is a marker of invasion, because it often develops as a monomer in malignant neoplasms. We investigated the expression of Lam\u20105 \u03b32 and its role for the invasiveness in EMPD. Paraffin\u2010embedded specimens of EMPD obtained from 36 patients were examined immunohistochemically for Lam\u20105 \u03b32. The cases adopted into this study comprised 16 cases of intraepidermal lesions and 20 cases with dermal invasion. The basement membrane seen in normal skin disappeared in one\u2010third of non\u2010invasive cases and in most invasive cases. The disappearance of Lam\u20105 \u03b32 in the basement membrane and its cytoplasmic expression was more observed in the invasive cases than non\u2010invasive cases. Expression of Lam\u20105 \u03b32 may be a biological marker to predict invasiveness of EMPD.<\/jats:p>","DOI":"10.1111\/apm.13086","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T06:06:56Z","timestamp":1601446016000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of laminin\u20105 gamma 2 chain predicts invasion of extramammary Paget\u2019s disease cell"],"prefix":"10.1111","volume":"129","author":[{"given":"Yuuko","family":"Tohmatsu","sequence":"first","affiliation":[{"name":"Departments of Surgery and Science Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johji","family":"Imura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Niigata Prefectural Central Hospital  Johetsu City, Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Minamisaka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Nagata","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Science Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamichi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Fujii","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Science Faculty of Medicine Academic Assembly University of Toyama  Toyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"187","article-title":"Paget's disease affecting the scrotum and penis","volume":"40","author":"HR C","year":"1889","journal-title":"Trans Pathol Soc"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01076.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199910000-00010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197711)40:5<2333::AID-CNCR2820400549>3.0.CO;2-#"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03242.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.4.2.2404817"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.4.6.2180767"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-10-0139"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0945-053X(94)90184-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1998.0250"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10117.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00131-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.114.3.567"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"11073","DOI":"10.1016\/S0021-9258(19)78093-4","article-title":"The complete primary structure for a novel laminin chain, the laminin B1k chain","volume":"269","author":"Gerecke DR","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.106.4.1083"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.3.615"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.10.742"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03291.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19960616)61:4<493::AID-JCB2>3.0.CO;2-J"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199908)188:4<361::AID-PATH363>3.0.CO;2-0"},{"key":"e_1_2_10_24_1","first-page":"896","article-title":"Expression of the gamma(2) chain of laminin\u20105 at the invasive front is associated with recurrence and poor prognosis in human esophageal squamous cell carcinoma","volume":"7","author":"Yamamoto H","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-7-105"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024142722640"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3182329e8f"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2012.01416.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01310.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.283"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03871.x"},{"key":"e_1_2_10_32_1","first-page":"5596","article-title":"Overexpression of laminin gamma2 chain monomer in invading gastric carcinoma cells","volume":"59","author":"Koshikawa N","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00211.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055714"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-019-02975-3"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.13086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T02:45:43Z","timestamp":1693881943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/apm.13086"],"URL":"https:\/\/doi.org\/10.1111\/apm.13086","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,21]]},"assertion":[{"value":"2020-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}