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During pandemic of coronavirus disease 2019 (COVID\u201019), it is noticed that the central nervous system involvement represented a truly significant moment in the history of some COVID\u201019 patients; indeed, clinical and radiological features published in literature regarding COVID\u201019 disease are consistent with a neurological involvement. It is also known that histopathological data related to SARS\u2010CoV2 infection have been published with considerable delay, which was even greater for neuropathological information. Moreover, many published data are incomplete, and often the lesions described are not directly related to the action of the virus. In this review, we collected the available radiological and neuropathological information, in order to delineate a more complete picture of the relationship between SARS\u2010Cov2 and brain, focusing our attention on the two most important neuroinvasion routes for the virus. We also highlighted what we consider methodological mistakes both in the autopsy procedures and brain study in COVID\u201019 deaths. We emphasize the need for a complete study of all the organs in case of autopsy. 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