{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:19:22Z","timestamp":1790313562327,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:00:00Z","timestamp":1606608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["000000000201904"],"award-info":[{"award-number":["000000000201904"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Circulating biological markers, such as miRNAs, hold the greatest possibilities to complement tissue biopsy and clinical diagnostic tests. The objective of this study was to evaluate the relative abundance of\u00a0three circulating\u00a0miRNAs\u00a0in serum from 17 HPV16\u2010positive patients with early cervical lesions known as Low\u2010Grade Squamous Intraepithelial Lesions (LSILs). The expression of circulating microRNAs miR\u201015b, miR\u201034a and miR\u2010218 in patients with LSILs was compared to 23 HPV\u2010negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. The expression levels of miR\u201015b remained unchanged while those of miRNAs 34a and 218 were relatively high in serum obtained from LSIL patients in comparison with healthy women (results were statistically significant with a p of\u00a0&lt;\u00a00.01 or\u00a0&lt;\u00a00.001). According to previous findings, miR\u201015b was overexpressed and miRNAs 34a and 218 were underexpressed in serum from SCC patients. Additionally, the mRNA expression levels of some selected gene targets were determined [Cyclin D1 (CCND1), Cyclin E1 (CCNE1), B\u2010cell lymphoma 2 (Bcl\u20102) and MutS\u00a0homolog 2 (MSH\u20102)]. All serum results correlated with tissue samples from the same patients. We propose that circulating\u00a0microRNAs can be valuable as molecular markers for the\u00a0early follow\u2010up of cervical carcinogenesis risk.<\/jats:p>","DOI":"10.1111\/apm.13093","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T16:06:01Z","timestamp":1603901161000},"page":"70-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Circulating miR\u201015b, miR\u201034a and miR\u2010218 as promising novel early low\u2010invasive biomarkers of cervical carcinogenesis"],"prefix":"10.1111","volume":"129","author":[{"given":"Rodolfo","family":"Ocadiz\u2010Delgado","sequence":"first","affiliation":[{"name":"Department of Genetics and Molecular Biology CINVESTAV\u2010IPN Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solangy","family":"Lizcano\u2010Meneses","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular 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