{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:13:09Z","timestamp":1781712789714,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>T cells play vital roles in the development and progression of acute coronary syndromes (ACS), including cytotoxicity mediated by CD8<jats:sup>+<\/jats:sup> T cells and immunoregulatory activity mediated by CD4<jats:sup>+<\/jats:sup> T cells. Interleukin (IL)\u20109\u2010secreting CD4<jats:sup>+<\/jats:sup> T cells (Th9 cells) were recently found to be involved in the onset of ACS. We investigated regulatory role of Th9 cells to CD8<jats:sup>+<\/jats:sup> T cells in patients with stable angina pectoris, unstable angina pectoris, and acute myocardial infarction (AMI). Circulating Th9 cells percentage, plasma IL\u20109 level, and PU.1 mRNA relative level was up\u2010regulated in AMI patients compared with controls. There was no significant difference of IL\u20109\u2010secreting CD8<jats:sup>+<\/jats:sup> T cells percentage among groups. CD8<jats:sup>+<\/jats:sup> T cells from AMI patients revealed increased cytotoxicity than those from controls, which presented as enhanced cytotolytic activity to target cells, increased interferon\u2010\u03b3 and tumor necrosis factor\u2010\u03b1 secretion, elevated perforin and granzyme B production, and reduced programmed death\u20101 and cytotoxic T lymphocyte\u2010associated protein 4. IL\u20109 stimulation did not affect proliferation, but promoted CD8<jats:sup>+<\/jats:sup> T\u2010cell cytotoxicity from both controls and AMI patients. IL\u20109\u2010secreting CD4<jats:sup>+<\/jats:sup> T cells were enriched in CD4<jats:sup>+<\/jats:sup>CCR4<jats:sup>\u2212<\/jats:sup>CCR6<jats:sup>\u2212<\/jats:sup>CXCR3<jats:sup>\u2212<\/jats:sup> cells. The enhancement of CD8<jats:sup>+<\/jats:sup> T\u2010cell cytotoxicity induced by CD4<jats:sup>+<\/jats:sup>CCR4<jats:sup>\u2212<\/jats:sup>CCR6<jats:sup>\u2212<\/jats:sup>CXCR3<jats:sup>\u2212<\/jats:sup> cells was dependent on IL\u20109 secretion. The present results indicated that up\u2010regulation of IL\u20109\u2010secreting CD4<jats:sup>+<\/jats:sup> T cells may contribute to pathogenesis of AMI through enhancement of CD8<jats:sup>+<\/jats:sup> T\u2010cell cytotoxicity.<\/jats:p>","DOI":"10.1111\/apm.13094","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T21:04:29Z","timestamp":1603919069000},"page":"91-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Interleukin\u20109\u2010secreting CD4<sup>+<\/sup> T cells regulate CD8<sup>+<\/sup> T cells cytotoxicity in patients with acute coronary syndromes"],"prefix":"10.1111","volume":"129","author":[{"given":"Hongsheng","family":"Gang","sequence":"first","affiliation":[{"name":"Department of Cardiology Wuhan Fourth Hospital Pu\u2019ai Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 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