{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T17:18:50Z","timestamp":1763399930201},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>A 22% increase in <jats:italic>Staphylococcus aureus<\/jats:italic> colonization was observed in Norwegian recruits during first year of military service. The aim was to determine whether specific genotypes caused the increase and to examine carriage status based on genotyping. Characterization of <jats:italic>S. aureus<\/jats:italic> from nose, throat and perineum sampled at enrolment and discharge included <jats:italic>spa<\/jats:italic> typing, MLVA, detection of PVL genes and antimicrobial susceptibility testing. <jats:italic>spa<\/jats:italic> typing demonstrated high and stable genetic diversity. The three most frequent <jats:italic>spa<\/jats:italic> types were found in 15% of recruits at enrolment and in 29% at discharge. Only t084 increased significantly (p\u00a0=\u00a00.02). Subtyping revealed that t084, t065 and t002 consisted of 13, 6 and 11 different MLVA types, respectively, at discharge. The military cohort (n\u00a0=\u00a0265) consisted of <jats:italic>S.\u00a0aureus<\/jats:italic> carriers of identical genotype (n\u00a0=\u00a099, 38%), carriers of non\u2010identical genotype (n\u00a0=\u00a052, 20%), intermittent carriers (n\u00a0=\u00a086, 33%) and non\u2010carriers (n\u00a0=\u00a027, 10%). Carrier status was indefinable for one recruit due to unavailable isolates for genotyping. Antibiotic resistance towards erythromycin, fusidic acid and clindamycin increased significantly and above national surveillance levels. The observed increase in <jats:italic>S.\u00a0aureus<\/jats:italic> colonization during military service was caused by many different genotypes implying many transmission routes. Genotype did not correlate with colonization niche or carriage status.<\/jats:p>","DOI":"10.1111\/apm.13106","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T15:44:10Z","timestamp":1608306250000},"page":"170-177","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is increased <i>Staphylococcus aureus<\/i> colonization during military service caused by specific genotypes? Molecular examination of long\u2010term carriage in a prospective cohort study"],"prefix":"10.1111","volume":"129","author":[{"given":"Anita","family":"Blomfeldt","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infection Control Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silje Bakken","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Helmersen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petri Kaarlo Juhani","family":"Eskonsipo","sequence":"additional","affiliation":[{"name":"Department of Troms\u00f8 Hemis Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hege Vangstein","family":"Aamot","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Akershus University Hospital L\u00f8renskog Norway"},{"name":"Department of Clinical Molecular Biology (EpiGen) Division of Medicine Akershus University Hospital and University of Oslo L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.859985"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01572-09"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12595"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2104-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.7139"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.10.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.07.014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.18.04.20380-en"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.35"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/313461"},{"key":"e_1_2_10_12_1","first-page":"627","article-title":"Increased incidence of methicillin\u2010resistant Staphylococcus aureus ST80, novel ST125 and SCCmecIV in the south\u2010eastern part of Norway during a 12\u2010year period","volume":"12","author":"Fossum AE","year":"2006","journal-title":"J Clin Microbiol"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5442-5448.2003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01979-14"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148772"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01352-12"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12049"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.26.11.2465-2466.1988"},{"key":"e_1_2_10_19_1","unstructured":"NORM\/NORM\u2010VET 2013.Usage of antimicrobial agents and occurrence of antimicrobial resistance in Norway. 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