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In contrast, it is often underestimated how much planning, including background and modifying experiments, is needed to establish a relevant infectious disease animal model. However, representative animal infectious models, well designed to test generated hypotheses, are useful to improve our understanding of pathogenesis, virulence factors and host response and to identify novel treatment candidates and therapeutic strategies. Such results can subsequently proceed to clinical testing if suitable. The present review aims at presenting all the pulmonary <jats:italic>Pseudomonas aeruginosa<\/jats:italic> infectious models we have knowledge of and the detailed descriptions of established animal models in our laboratory focusing on macrolide therapy are presented.<\/jats:p>","DOI":"10.1111\/apm.13161","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T07:49:52Z","timestamp":1623484192000},"page":"458-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Animal models of chronic and recurrent <i>Pseudomonas\u00a0aeruginosa<\/i> lung infection: significance of macrolide treatment"],"prefix":"10.1111","volume":"130","author":[{"given":"Kim","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kishi","sequence":"additional","affiliation":[{"name":"Oitaken Kouseiren Tsurumi Hospital Tsurumi  Beppu City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kawasaki Medical School General Medical Center  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"\u00d8strup Jensen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology Costerton Biofilm Center University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Heydorn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nephrology Nordsj\u00e6llands Hospital  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Hentzer","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology H. 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