{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:34:19Z","timestamp":1752230059450,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001658","name":"Minerva Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004756","name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>P\u2010cadherin (CDH3) is a cell\u2010to\u2010cell adhesion molecule that regulates several cellular homeostatic processes in normal tissues. Lack of CDH3 expression is associated with aggressive behavior in oral squamous cell carcinoma (OSCC). Previous studies have shown that CDH3 is downregulated in high\u2010grade OSCC and its reduced expression is predictive for poorer survival. The aim of this study was to evaluate the expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma (TSCC). A retrospective series of 211 TSCC and 50 lymph node samples were stained immunohistochemically with polyclonal antibody (anti\u2010CDH3). CDH3 expression was assessed semi\u2010quantitatively with light microscopy. Fisher\u2019s exact test was used to compare patient and tumor characteristics, and the correlations were tested by Spearman correlation. Survival curves were drawn by the Kaplan\u2013Meier method and analyzed by the log\u2010rank test. Univariate and multivariate Cox regression was used to estimate the association between CDH3 expression and survival. CDH3 expression did not affect TSCC patient\u2019s disease\u2010specific survival or overall survival. Strong CDH3 expression in the primary tumor predicted poor disease\u2010specific and overall survival in patients with recurrent disease. CDH3 expression in lymph nodes without metastasis was negative in all cases. CDH3 expression was positive in all lymph node metastases with extranodal extension. In contrast to previous report about the prognostic value of CDH3 in OSCC, we were not able to validate the result in TSCC.<\/jats:p>","DOI":"10.1111\/apm.13176","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T08:41:07Z","timestamp":1632818467000},"page":"717-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-5426","authenticated-orcid":false,"given":"Miia","family":"Sepp\u00e4l\u00e4","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Jauhiainen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanni","family":"Tervo","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Al\u2010Samadi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland"},{"name":"Translational Immunology Research Program Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Rautiainen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Tampere University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Oral and Maxillofacial Diseases Clinicum Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Cancer and Translational Medicine Research Unit University of Oulu Oulu Finland"},{"name":"Medical Research Centre Oulu University Hospital Oulu Finland"},{"name":"Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisa","family":"Lehti","sequence":"additional","affiliation":[{"name":"Research Programs Unit, Genome\u2010Scale Biology Biomedicum Helsinki University of Helsinki Helsinki Finland"},{"name":"Department of Microbiology, Tumor, and Cell Biology (MTC) Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"Monni","sequence":"additional","affiliation":[{"name":"Applied Tumor Genomics Research Program Faculty of Medicine Biomedicum Helsinki University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sampsa","family":"Hautaniemi","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli","family":"Tynninen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki and HUSLAB Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Helsinki HUS Helsinki University Hospital Helsinki Finland"},{"name":"Division of Ear, Nose and Throat Diseases Department of Clinical Sciences, Intervention and Technology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"M\u00e4kinen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Paavonen","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories and Department of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"Toppila\u2010Salmi","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital Haartman Institute University of Helsinki University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2982"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01563.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0158-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.06.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508155200"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21841"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.02.005"},{"key":"e_1_2_8_9_1","first-page":"9498","article-title":"Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma","volume":"15","author":"Ma C","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27710"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-1-20"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24744"},{"key":"e_1_2_8_13_1","unstructured":"Finnish Cancer Registry.2018.www.cancerregistry.fi"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(93)90029-P"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003053"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.4.629"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10083"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6707"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.102.1.7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.6.2649"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3068"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.05.004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.10.3185"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0448-4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11933"},{"key":"e_1_2_8_26_1","first-page":"1089","article-title":"P\u2010cadherin expression predicts clinical outcome in oral squamous cell carcinomas","volume":"19","author":"Muzio LL","year":"2004","journal-title":"Histol Histopathol"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-011-9710-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.187"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1343"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0684-7"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3545"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20858"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.03.046"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp175"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt211"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201800061"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncoscience.370"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814556061"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200304000-00010"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2015.09.005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940101)73:1<187::AID-CNCR2820730132>3.0.CO;2-J"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4359-1"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183611"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)01378-8"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12522"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.13176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:08:55Z","timestamp":1693206535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/apm.13176"],"URL":"https:\/\/doi.org\/10.1111\/apm.13176","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"type":"print","value":"0903-4641"},{"type":"electronic","value":"1600-0463"}],"subject":[],"published":{"date-parts":[[2021,11,3]]},"assertion":[{"value":"2021-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}