{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:23:42Z","timestamp":1776731022117,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>The aim was to determine the accuracy of anterior nasal swab in rapid antigen (Ag) tests in a low SARS\u2010CoV\u20102 prevalence and massive screened community. Individuals, aged 18\u2009years or older, who self\u2010booked an appointment for real\u2010time reverse transcriptase\u2010polymerase chain reaction (RT\u2010PCR) test in March 2021 at a public test center in Copenhagen, Denmark were included. An oropharyngeal swab was collected for RT\u2010PCR testing, followed by a swab from the anterior parts of the nose examined by Ag test (SD Biosensor). Accuracy of the Ag test was calculated with RT\u2010PCR as reference. We included 7074 paired conclusive tests (<jats:italic>n<\/jats:italic>\u2009=\u20093461, female: 50.7%). The median age was 48\u2009years (IQR: 36\u201357\u2009years). The prevalence was 0.9%, that is, 66 tests were positive on RT\u2010PCR. Thirty\u2010two had a paired positive Ag test. The sensitivity was 48.5% and the specificity was 100%. This study conducted in a low prevalence setting in a massive screening set\u2010up showed that the Ag test had a sensitivity of 48.5% and a specificity of 100%, that is, no false positive tests. The lower sensitivity is a challenge especially if Ag testing is not repeated frequently allowing this scalable test to be a robust supplement to RT\u2010PCR testing in an ambitious public SARS\u2010CoV\u20102 screening.<\/jats:p>","DOI":"10.1111\/apm.13189","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T20:27:03Z","timestamp":1636576023000},"page":"95-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Accuracy of anterior nasal swab rapid antigen tests compared with RT\u2010PCR for massive SARS\u2010CoV\u20102 screening in low prevalence population"],"prefix":"10.1111","volume":"130","author":[{"given":"Kathrine Kronberg","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob Schmidt","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Todsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Copenhagen Academy for Medical Education and Simulation Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Kirkby","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freddy","family":"Lippert","sequence":"additional","affiliation":[{"name":"Copenhagen Emergency Medical Services University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Marie","family":"Vangsted","sequence":"additional","affiliation":[{"name":"Testcenter Danmark Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Klokker","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Analyser og prognoser for epidemiens udviklingAvailable online:https:\/\/covid19.ssi.dk\/analyser\u2010og\u2010prognoser\/analyser\u2010og\u2010prognoser\u2010for\u2010epidemien\u2010udvikling. 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