{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:44:23Z","timestamp":1785851063472,"version":"3.56.0"},"reference-count":83,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Biofilm infections involving orthopedic implants are a global problem. They contribute to severe complications and mortality, as well as increased use of antibiotic treatments and development of antibiotic\u2010resistant microorganisms. More than 1 million hip and knee arthroplasties are performed each year in the United States. These hard\u2010to\u2010treat infections lead to patient distress, increased morbidity, and high financial costs to both patients and healthcare systems. There is a need to improve the diagnosis of such biofilm infections to allow for earlier detection and treatment. Current diagnostics rely on clinical signs for infections such as loss of function, fever, rubor, patient history of the predisposing condition, persisting infection, failure of antibiotic treatment, and documentation of antibiotic failure. Below, we present a framework which outlines the data gaps in the conventional laboratory techniques used in clinical diagnostics; we also discuss promising novel diagnostic methods which are currently used solely in research. It is critical to assess these novel infection diagnostic techniques and address the data gaps and clinical hesitance preventing application in a clinical setting. Additionally, the combination of conventional and novel diagnostic technologies would streamline the diagnostic process of biofilm infections associated with orthopedic implants.<\/jats:p>","DOI":"10.1111\/apm.13197","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T09:11:36Z","timestamp":1638609096000},"page":"59-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Current and novel diagnostics for orthopedic implant biofilm infections: a review"],"prefix":"10.1111","volume":"130","author":[{"given":"Dana","family":"Ronin","sequence":"first","affiliation":[{"name":"Department of Civil and Environmental Engineering University of Maryland College Park Maryland USA"},{"name":"Fischell Department of Bioengineering University of Maryland College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Boyer","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering University of Maryland College Park Maryland USA"},{"name":"Fischell Department of Bioengineering University of Maryland College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Alban","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering University of Maryland College Park Maryland USA"},{"name":"Fischell Department of Bioengineering University of Maryland College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman M.","family":"Natoli","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birthe Veno","family":"Kjellerup","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering University of Maryland College Park Maryland USA"},{"name":"Fischell Department of Bioengineering University of Maryland College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2018.03.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-85709-844-3.00009-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpet.2019.11.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12676"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02192"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12671"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00132-020-03948-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2014.10.024"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"issue":"6","key":"e_1_2_7_11_1","first-page":"RA89","article-title":"Orthopedics and biofilm \u2013 what do we know? 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