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Recent studies have demonstrated how specific bacteria can influence the major CRC\u2010related pathways, i.e., Wnt, PI3K\u2010Akt, MAPK, TGF\u2010\u03b2, EGFR, mTOR, and p53. In order to advance the current understanding and facilitate the choice of pathways to investigate, we have systematically collected and summarized the current knowledge within bacterial altered major pathways in CRC. Several pro\u2010tumorigenic and anti\u2010tumorigenic bacterial species and their respective metabolites interfere with the major signaling pathways addressed in this review. Not surprisingly, some of these studies investigated known CRC drivers, such as <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Fusobacterium nucleatum<\/jats:italic>, and <jats:italic>Bacteroides fragilis<\/jats:italic>. 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