{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:34:01Z","timestamp":1791891241884,"version":"4.3.4"},"reference-count":73,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) is the cause of coronavirus infectious disease (COVID\u201019) and has rapidly spread worldwide, causing serious problems to the healthcare systems of many countries and hundreds of thousand deaths. In this review we discuss data from the literature to understand whether the various districts of the male reproductive system may represent another vulnerable target for SARS\u2010CoV\u20102. Studies were searched from electronic databases such as Google Scholar, PubMed, Scopus, and COVID\u201019 specific databases such as LitCovid, until July 31, 2021. It appears that SARS\u2010CoV\u20102 virus infection not only causes damage to the respiratory system, but could have a serious impact on the reproductive system of male patients modulating many physiological processes. Like some other infections, SARS\u2010CoV\u20102 also leads to a worsening of semen quality and an increase in oxidative stress (OS) levels. However, due to the limited number of studies, it is unclear whether this deterioration in semen parameters is temporary or lasts over time. It is certainly important that patients' reproductive function is monitored after coronavirus infection to avoid problems in reproductive health in the future.<\/jats:p>","DOI":"10.1111\/apm.13210","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T17:44:07Z","timestamp":1643910247000},"page":"243-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Could SARS\u2010CoV\u20102 infection affect male fertility and sexuality?"],"prefix":"10.1111","volume":"130","author":[{"given":"Nicola","family":"delli Muti","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Clinical and Molecular Sciences Polytechnic University of Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Finocchi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Clinical and Molecular Sciences Polytechnic University of Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Tossetta","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Polytechnic University of Marche Ancona Italy"},{"name":"Clinic of Obstetrics and Gynaecology Department of Clinical Sciences Polytechnic University of Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmaria","family":"Salvio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Clinical and Molecular Sciences Polytechnic University of Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Cutini","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Clinical and Molecular Sciences Polytechnic University of Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Marzioni","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Polytechnic University of Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Balercia","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Clinical and Molecular Sciences Polytechnic University of Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2019.07.001"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-020-09944-5"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13791"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-00662-x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2020-0156"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.032"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"issue":"17","key":"e_1_2_14_9_1","first-page":"4180","article-title":"Prostate\u2010localized and androgen\u2010regulated expression of the membrane\u2010bound serine protease TMPRSS2","volume":"59","author":"Lin B","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2507"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12030254"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.044776"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2020.05.009"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15541"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00152"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21688"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2021.03.004"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01350-1"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12821"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.607179"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12119"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.8292"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260187"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510531"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.05.028"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.04.024"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa050"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa325"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01580-x"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-020-00344-0"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12848"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01261-1"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12939"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13912"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100604"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0487-LE"},{"key":"e_1_2_14_37_1","article-title":"ACE2 expression in kidney and testis may cause kidney and testis infection in COVID\u201019 patients","volume":"7","author":"Fan C","year":"2020","journal-title":"Front Med"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab026"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13019"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14157"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-69535-8_11"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00604-5"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.210055"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.4081\/cp.2020.1271"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13003"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.567824"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.683529"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9405-9"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12993"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420188211010105"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027072"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1198-9"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc1530"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.32598\/bcn.11.covid19.1168.2"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30216-3"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.12.008"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154955"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(91)90310-2"},{"issue":"4","key":"e_1_2_14_59_1","first-page":"259","article-title":"The clinical use of albumin: the point of view of a specialist in intensive care","volume":"7","author":"Caironi P","year":"2009","journal-title":"Blood Transfus"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0041"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-20-0382"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/2090598X.2019.1599624"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/13625187.2020.1787376"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2020.04.019"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.03.044"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12005"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1739565"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.12.039"},{"issue":"4","key":"e_1_2_14_69_1","first-page":"1565","article-title":"Post interferon therapy decreases male fertility through gonadotoxic effect","volume":"31","author":"Bukhari SA","year":"2018","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.05.001"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.1755"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02364-6"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-021-00769-x"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01290-w"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.13210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:21:54Z","timestamp":1692876114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,5]]},"references-count":73,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/apm.13210"],"URL":"https:\/\/doi.org\/10.1111\/apm.13210","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,5]]},"assertion":[{"value":"2021-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}