{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:20:40Z","timestamp":1772637640371,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>This study examined whether gene polymorphisms for toll\u2010like receptor 10 (<jats:italic>TLR10<\/jats:italic>) associated with the susceptibility to and outcomes of bacterial meningitis (BM) in Angolan children. The study cohort consisted of 190 BM patients and the determination of ten single\u2010nucleotide polymorphisms (SNPs) by Sanger sequencing. Patients with BM caused by <jats:italic>Streptococcus pneumoniae<\/jats:italic> who carried the following variants of <jats:italic>TLR10<\/jats:italic> SNPs exhibited an increased risk of coexisting pneumonia: rs10004195 (T\u2009&gt;\u2009A) (p\u2009=\u20090.025), rs10856837 (G\u2009&gt;\u2009A) (p\u2009=\u20090.018) or rs11096956 (G\u2009&gt;\u2009T) (p\u2009=\u20090.010). Yet, <jats:italic>TLR10<\/jats:italic> SNPs rs11466652 (A\u2009&gt;\u2009G), rs10856837 (G\u2009&gt;\u2009A) and rs11096956 (G\u2009&gt;\u2009T) influenced the protein levels in the cerebrospinal fluid (CSF). Moreover, compared with the wild type, patients with pneumococcal meningitis carrying a variant genotype of <jats:italic>TLR10<\/jats:italic> SNP rs11466648 (A\u2009&gt;\u2009G) exhibited an increased risk of developing blindness (p\u2009=\u20090.025), whereas patients with <jats:italic>TLR10<\/jats:italic> SNP rs10004195 (T\u2009&gt;\u2009A) exhibited a lower risk of convulsions at admission (p\u2009=\u20090.039) and a lower risk of altered consciousness (p\u2009=\u20090.029). This study suggests a relationship exists between coexisting pneumonia, protein levels in CSF, blindness, convulsions and an altered consciousness with genetic variations of <jats:italic>TLR10<\/jats:italic> in BM in Angolan children.<\/jats:p>","DOI":"10.1111\/apm.13213","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T17:34:03Z","timestamp":1644082443000},"page":"221-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gene polymorphisms of TLR10: effects on bacterial meningitis outcomes in Angolan children"],"prefix":"10.1111","volume":"130","author":[{"given":"Elina","family":"Tenhu","sequence":"first","affiliation":[{"name":"Institute of Biomedicine Research Centre of Infections and Immunity University of Turku Turku 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