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This was a cross\u2010sectional study conducted in Mwanza, Northwestern Tanzania. We used data of 668 participants attained from two sub\u2010studies of CICADA study. Mean age was 40 (SD 11.5) years, 402 (61.7%) were females and 157 (24.1%) had SCT. PLWH were 422 (64.7%), of these, 80 (18.9%) were on ART. People with SCT had higher risk of having an isolated \u03b2\u2010cell dysfunction compared to those without SCT (RRR\u2009=\u20091.82, CI: 1.10, 3.01, p\u2009=\u20090.02). People with SCT but without HIV infection had lower average acceleration on the trunk longitudinal axis (ACCx) and higher level of self\u2010reported physical activity. 30\u2009min oral glucose tolerance test among PLWH on ART was higher in those with SCT compared to those without SCT. People with SCT are at higher risk of having \u03b2\u2010cell dysfunction and those with SCT on ART are at more risk of developing diabetes. Future studies to investigate the interaction between SCT and HIV\/ART on risk of diabetes should be considered.<\/jats:p>","DOI":"10.1111\/apm.13214","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T14:53:15Z","timestamp":1644936795000},"page":"230-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of sickle cell trait with \u03b2\u2010cell dysfunction and physical activity in adults living with and without HIV in Tanzania"],"prefix":"10.1111","volume":"130","author":[{"given":"Belinda V.","family":"Kweka","sequence":"first","affiliation":[{"name":"Mwanza Research Centre National Institute for Medical Research Mwanza Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyprian","family":"Fredrick","sequence":"additional","affiliation":[{"name":"Mwanza Research Centre National Institute for Medical Research Mwanza 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