{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:56:20Z","timestamp":1780516580383,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>The prevalence of vancomycin\u2010resistant <jats:italic>Enterococcus faecium<\/jats:italic> has increased rapidly, and in Denmark, we are facing an endemic outbreak situation in hospitals. The aim of this study was to use whole\u2010genome sequencing (WGS) and core genome multilocus sequencing typing (cgMLST) to determine the duration of VREfm outbreaks and thereby evaluate the effect of our infection control strategies. We included all VREfm isolates from six hospitals in the Capital Region of Denmark that were sequenced between 2012 and 2020. Ward data were collected from our laboratory information system. A ward outbreak was defined as two patient samples from the same ward within a period of 30\u2009days belonging to the same cgMLST cluster. cgMLST complex types were determined using Ridom SeqSphere v7.2.3, where a maximum of 20 allelic differences between isolates defines a cluster. We included 1690 patient isolates between 2012 and 2020. Our collection consisted of 45 unique clusters and 227 ward outbreaks. The median duration of outbreaks was 20\u2009days. We reported a median outbreak duration of VREfm outbreaks based on WGS data to be 20\u2009days, and thus concluded that our infection control precautions are adequate.<\/jats:p>","DOI":"10.1111\/apm.13216","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T06:28:05Z","timestamp":1646634485000},"page":"323-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The use of core genome multilocus sequence typing to determine the duration of vancomycin\u2010resistant <i>Enterococcus faecium<\/i> outbreaks"],"prefix":"10.1111","volume":"130","author":[{"given":"Maja Johanne S\u00f8ndergaard","family":"Knudsen","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology Copenhagen University Hospital \u2013 Amager and Hvidovre  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Maria 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