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IL\u201022 furthermore regulates innate immune responses as it induces the production of antimicrobial proteins and neutrophil\u2010attracting chemokines. IL\u201022 plays an important role in wound healing and in the protection against skin infections. However, IL\u201022 can also contribute to the pathogenesis of several inflammatory skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis. In this review, current information regarding the structure, function and regulation of IL\u201022 is discussed with a special focus on the role of IL\u201022 in the skin and in skin diseases.<\/jats:p>","DOI":"10.1111\/apm.13221","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T18:28:31Z","timestamp":1647973711000},"page":"314-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Role of IL\u201022 in homeostasis and diseases of the skin"],"prefix":"10.1111","volume":"130","author":[{"given":"Daniel Villalba","family":"Lopez","sequence":"first","affiliation":[{"name":"The LEO Foundation Skin Immunology Research Center Department of Immunology and Microbiology Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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