{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:53:04Z","timestamp":1726851184983},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002918","name":"Gentofte Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>The aim of this study was to assess L\u2010lactate and D\u2010lactate in endotracheal aspirate from intubated patients hospitalized at the intensive care unit and explore their use as diagnostic biomarkers for inflammation and lower respiratory tract infections (LRTI). Tracheal aspirates from 91 intubated patients were obtained at time of intubation and sent for microbiological analyses, neutrophil count, and colorimetric lactate measurements. We compared the concentration of lactate from patients with microbiological verified LRTI or clinical\/radiological suspicion of LRTI with a control group. In addition, associations between inflammation and the lactate isomers were examined by correlating L\u2010lactate and D\u2010lactate with sputum neutrophils and clinical assessments. The concentration of L\u2010lactate was increased in aspirates with verified or suspected LRTI (p\u2009&lt;\u20090.001) relative to the control group at Day 0. Connections between L\u2010lactate and inflammation were indicated by the correlation between neutrophils and L\u2010lactate (p\u2009&lt;\u20090.001). We found no increase in sputum D\u2010lactate from patients with verified or suspected LRTI relative to the control group and D\u2010lactate was not correlated with neutrophils. L\u2010lactate was found to be a potential indicator for inflammation and LRTI at the time of intubation. An association was found between neutrophil count and L\u2010lactate. Interestingly, the increase of L\u2010lactate in the control group after intubation may suggest that intubation challenges the host response by inflicting tissue damage or by introducing infectious microbes.<\/jats:p>","DOI":"10.1111\/apm.13224","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T18:19:26Z","timestamp":1648577966000},"page":"507-514","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Endotracheal lactate reflects lower respiratory tract infections and inflammation in intubated patients"],"prefix":"10.1111","volume":"130","author":[{"given":"Mette","family":"Kolpen","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Dalby S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and 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