{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:26:32Z","timestamp":1784118392698,"version":"3.55.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Cytokeratin 13 (CK13) is a type I acidic low molecular weight cytokeratin, which is mainly expressed in urothelium and in the squamous epithelium of various sites of origin. Loss of CK13 has been implicated in the development and progression of squamous epithelial neoplasms. To comprehensively determine CK13 expression in normal and neoplastic tissues, a tissue microarray containing 10,439 samples from 131 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. CK13 immunostaining was detectable in 42 (32.1%) of the 131 tumor categories including 24 (18.3%) tumor types with at least one strongly positive case. The highest rate of positive staining was found in various urothelial neoplasms (52.1\u201392.3%) including Brenner tumor of the ovary (86.8%) and in squamous cell carcinomas from various sites of origin (39.1\u201377.6%), Warthin tumors of parotid glands (66.7%), adenosquamous carcinomas of the cervix (33.3%), thymomas (16.0%), and endometroid carcinomas of the ovary (15.3%). Twenty other epithelial or germ cell neoplasms showed \u2013 a usually weak \u2013 CK13 positivity in less than 15% of the cases. In bladder cancer, reduced CK13 expression was linked to high grade and advanced stage (p\u2009&lt;\u20090.0001 each). In squamous cell carcinoma of the cervix, reduced CK13 immunostaining was related to high grade (p\u00a0=\u00a00.0295) and shortened recurrence\u2010free (p\u00a0=\u00a00.0094) and overall survival (p\u00a0=\u00a00.0274). In a combined analysis of 1,151 squamous cell carcinomas from 11 different sites of origin, reduced CK13 staining was linked to high grade (p\u00a0=\u00a00.0050). Our data provide a comprehensive overview on CK13 expression in normal and neoplastic human tissues. CK13 expression predominates in urothelial neoplasms and in squamous cell carcinomas of different organs, and a loss of CK13 expression is associated with aggressive disease in these tumors.<\/jats:p>","DOI":"10.1111\/apm.13280","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T17:10:18Z","timestamp":1666372218000},"page":"77-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cytokeratin 13 (<scp>CK13<\/scp>) expression in cancer: a tissue microarray study on 10,439 tumors"],"prefix":"10.1111","volume":"131","author":[{"given":"Maximilian","family":"Lennartz","sequence":"first","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena Sofia","family":"Ullmann","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Gorbokon","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ria","family":"Uhlig","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian Dwertmann","family":"Rico","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kind","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Reiswich","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Viehweger","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kluth","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Hube\u2010Magg","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bernreuther","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"B\u00fcscheck","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devita","family":"Putri","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till S.","family":"Clauditz","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Fraune","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hinsch","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Krech","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Institute of Pathology Clinical Center Osnabrueck  Osnabrueck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lebock","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Institute of Pathology Clinical Center Osnabrueck  Osnabrueck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Steurer","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike","family":"Burandt","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Minner","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas H.","family":"Marx","sequence":"additional","affiliation":[{"name":"Department of Pathology Academic Hospital Fuerth  Fuerth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Simon","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Sauter","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Menz","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-019-9864-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.12.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2009.01066.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10316"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583500003516"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(86)90429-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00297-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01606063"},{"issue":"11","key":"e_1_2_7_10_1","first-page":"1425","article-title":"Staining patterns of keratins in the human urinary tract","volume":"24","author":"Alonso A","year":"2009","journal-title":"Histol Histopathol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/33.5.2580881"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2017.02.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00094-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1557-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2020.01.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12262"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941015)74:8<2314::AID-CNCR2820740816>3.0.CO;2-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.01.021"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000164110"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1202-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03759.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1999.eos107605.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.12.007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26826"},{"issue":"2","key":"e_1_2_7_25_1","first-page":"215","article-title":"Loss of cytokeratin 13 expression in squamous cell carcinoma of the tongue is a possible sign for local recurrence","volume":"26","author":"Yanagawa T","year":"2007","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13092"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb01182.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70029-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.9.679"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21406"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20636"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191342"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.28951"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2003.01472.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2003.12.007"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3204-7_3"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0798-844"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000315"},{"issue":"6","key":"e_1_2_7_39_1","first-page":"1389","article-title":"Cytokeratin expression patterns in metastatic transitional cell carcinoma of the urinary tract. An immunohistochemical study comparing local tumor and autologous metastases","volume":"139","author":"Schaafsma HE","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12965"},{"key":"e_1_2_7_41_1","volume-title":"StatPearls","author":"Babak A","year":"2022"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2010-0640-RS"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197507)36:1<1::AID-CNCR2820360102>3.0.CO;2-4"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198301000-00002"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-014-9890-7"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930050410"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v7.i9.132"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880332"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0090"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204040"},{"key":"e_1_2_7_51_1","first-page":"184602","article-title":"IL1RN and KRT13 expression in bladder cancer: association with pathologic characteristics and smoking status","volume":"2014","author":"Worst TS","year":"2014","journal-title":"Ther Adv Urol"},{"issue":"20","key":"e_1_2_7_52_1","first-page":"4782","article-title":"Loss of adipocyte\u2010type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas","volume":"56","author":"Celis JE","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00492389"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3364-8"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0444-0"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12125"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0303-6987.2002.028.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230351"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.29656"},{"issue":"1","key":"e_1_2_7_60_1","first-page":"17","article-title":"Reduced expression of cytokeratin 4 and 13 is a valuable marker for histologic grading of esophageal squamous intraepithelial neoplasia","volume":"59","author":"Takashima M","year":"2012","journal-title":"J Med Dent Sci"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2436-8"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.210"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3321"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0560-6"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1099"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700006-MCP200"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000067683.84284.66"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.13280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T04:27:31Z","timestamp":1692505651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,7]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/apm.13280"],"URL":"https:\/\/doi.org\/10.1111\/apm.13280","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,7]]},"assertion":[{"value":"2022-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}