{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:40:35Z","timestamp":1790671235160,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>The human ocular surface hosts a bacterial assemblage that integrates a diverse and complex microbiome. This bacterial microbiota is part of a healthy eye and plays a protective role in it. However, this ocular bacterial assemblage may alter the ocular surface inflammation response and can influence the development and progression of dry eye disease. For this reason, the present review describes the changes generated on the ocular surface by bacterial assemblages during the development of dry eye disease. Likewise, the interaction of this microbiota with the other inflammatory factors that influence the development of this disease is analyzed, as well as the use of treatments focused on modifying the bacteria on the ocular surface.<\/jats:p>","DOI":"10.1111\/apm.13285","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T12:38:32Z","timestamp":1669898312000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An insight on the eye bacterial microbiota and its role on dry eye disease"],"prefix":"10.1111","volume":"131","author":[{"given":"Joicye","family":"Hern\u00e1ndez\u2010Zulueta","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Molecular Centro Universitario de Ciencias Biol\u00f3gicas y Agropecuarias, Universidad de Guadalajara  Zapopan Jalisco Mexico"},{"name":"Laboratorio de Ecolog\u00eda Molecular, Microbiolog\u00eda y Taxonom\u00eda (LEMITAX), Departamento de Ecolog\u00eda Centro Universitario de Ciencias Biol\u00f3gicas y Agropecuarias, Universidad de Guadalajara  Zapopan Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Navarro\u2010Partida","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud  Zapopan Jalisco Mexico"},{"name":"Centro de Retina Medica y Quir\u00fargica, S.C. Centro Medico Puerta de Hierro  Zapopan Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Eduardo","family":"S\u00e1nchez\u2010Aguilar","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud  Zapopan Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor Daniel Santa","family":"Cruz\u2010Pavlovich","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud  Zapopan Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Rodrigo","family":"Castro\u2010Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud  Zapopan Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gonz\u00e1lez\u2010De la Rosa","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud  Zapopan Jalisco Mexico"},{"name":"Centro de Retina Medica y Quir\u00fargica, S.C. Centro Medico Puerta de Hierro  Zapopan Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2012.12.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/NHH.0000000000000652"},{"issue":"5","key":"e_1_2_7_4_1","first-page":"71","article-title":"The pathophysiology, diagnosis, and treatment of dry eye disease","volume":"112","author":"Messmer EM","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.06.033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091439"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8030088"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315026"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071398"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2015.1088953"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4596"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.08.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00639"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.06.014"},{"issue":"2","key":"e_1_2_7_16_1","first-page":"240","article-title":"Dry eye: an inflammatory ocular disease","volume":"9","author":"Hessen M","year":"2014","journal-title":"J Ophthalmic Vis Res"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13526"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228443"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318242fd60"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2019.1570526"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6939"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1045542"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0099-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.68.8.524"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199110010-00010"},{"key":"e_1_2_7_26_1","first-page":"2291","article-title":"Relation of cholesterol\u2010stimulated Staphylococcus aureus growth to chronic blepharitis","volume":"34","author":"Shine WE","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00735-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01347-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00140068-200301001-00019"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000330"},{"key":"e_1_2_7_31_1","first-page":"343","article-title":"Comparative study of bacterial status from conjunctival sac of the elder Qiang minority and Han people with dry eye in Sichuan","volume":"5","author":"Zhang Y","year":"2012","journal-title":"China Int J Ophthalmol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2016.12.003"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.72.6.448"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200211000-00017"},{"key":"e_1_2_7_35_1","first-page":"169","article-title":"A simple alternative method for rapid detection of slime produced by Staphylococcus epidermidis isolates in bacterial keratitis","volume":"114","author":"Nayak N","year":"2001","journal-title":"Indian J Med Res"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0588"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000225716.85382.7b"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-019-9127-2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68952-w"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997g"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224203"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.07.014"},{"issue":"2","key":"e_1_2_7_43_1","first-page":"NC05","article-title":"Efficacy of green tea extract for treatment of dry eye and meibomian gland dysfunction: a double\u2010blind randomized controlled clinical trial study","volume":"11","author":"Nejabat M","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12849"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.12.004"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574884712666170704145046"},{"key":"e_1_2_7_47_1","first-page":"181","article-title":"The mixture of bifidobacterium associated with fructooligosaccharides reduces the damage of the ocular surface","volume":"168","author":"Chisari G","year":"2017","journal-title":"Clin Ter"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16595"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2018.1497664"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122645"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2690"},{"key":"e_1_2_7_52_1","first-page":"463","article-title":"Microbiology synergism between tear substitutes and symbiotic treatment of patients with irritable bowel syndrome","volume":"32","author":"Chisari G","year":"2016","journal-title":"Acta Med Mediterr"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2015.12.005"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111166"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61822-5"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2014.07.002"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13285","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.13285","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:06:05Z","timestamp":1692569165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/apm.13285"],"URL":"https:\/\/doi.org\/10.1111\/apm.13285","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"2022-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}