{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:58:41Z","timestamp":1768679921529,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>We investigated if diarrhoea\u2010causing bacteria, including <jats:italic>Yersinia<\/jats:italic> species, could mimic the symptoms of appendicitis and lead to surgery. This prospective observational cohort study (NCT03349814) included adult patients undergoing surgery for suspected appendicitis. Rectal swabs were analysed with polymerase chain reaction (PCR) for <jats:italic>Yersinia<\/jats:italic>, <jats:italic>Campylobacter<\/jats:italic>, <jats:italic>Salmonella<\/jats:italic>, <jats:italic>Shigella<\/jats:italic> and <jats:italic>Aeromonas<\/jats:italic> spp. Blood samples were analysed routinely and with an in\u2010house ELISA serological test for <jats:italic>Yersinia enterocolitica<\/jats:italic> antibodies. We compared patients without appendicitis and patients with appendicitis confirmed by histopathology. The outcomes included PCR\u2010confirmed infection with <jats:italic>Yersinia<\/jats:italic> spp., serologic\u2010confirmed infection with <jats:italic>Y.\u2009enterocolitica<\/jats:italic>, PCR\u2010confirmed infection with other diarrhoea\u2010causing bacteria and <jats:italic>Enterobius vermicularis<\/jats:italic> confirmed by histopathology. A total of 224 patients were included, 51 without and 173 with appendicitis, and followed for 10\u2009days. PCR\u2010confirmed infection with <jats:italic>Yersinia<\/jats:italic> spp. was found in one patient (2%) without appendicitis and no patients (0%) with appendicitis (p\u2009=\u20090.23). Serology was positive for <jats:italic>Y. enterocolitica<\/jats:italic> for the same patient without appendicitis and two patients with appendicitis (p\u2009=\u20090.54). <jats:italic>Campylobacter<\/jats:italic> spp. were detected in 4% vs 1% (p\u2009=\u20090.13) of patients without and with appendicitis, respectively. Infection with <jats:italic>Yersinia<\/jats:italic> spp. and other diarrhoea\u2010causing microorganisms in adult patients undergoing surgery for suspected appendicitis was rare.<\/jats:p>","DOI":"10.1111\/apm.13311","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T09:14:27Z","timestamp":1679130867000},"page":"284-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diarrhoea\u2010causing microorganisms are rare in adult patients undergoing diagnostic laparoscopy for suspected appendicitis: a prospective observational cohort study"],"prefix":"10.1111","volume":"131","author":[{"given":"Siv","family":"Fonnes","sequence":"first","affiliation":[{"name":"Centre for Perioperative Optimisation, Department of Surgery Copenhagen University Hospital \u2010 Herlev and Gentofte  Herlev 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