{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:49:52Z","timestamp":1792705792173,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n                    Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture\u2010related infection patient, all with staphylococci\u2010positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna\u2013canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion.\n                  <\/jats:p>","DOI":"10.1111\/apm.13312","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T09:53:41Z","timestamp":1679565221000},"page":"325-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Bacterial invasion of the submicron osteocyte lacuna\u2013canaliculi network (\n                    <scp>OLCN<\/scp>\n                    ): a part of osteomyelitis disease biology"],"prefix":"10.1111","volume":"131","author":[{"given":"Louise Kruse","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Science, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie 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