{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:10:41Z","timestamp":1792177841457,"version":"4.4.0"},"reference-count":81,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>The prevalence of invasive pulmonary aspergillosis (IPA) is growing in critically ill patients in the intensive care unit (ICU). It is increasingly recognized in immunocompetent hosts and immunocompromised ones. IPA frequently complicates both severe influenza and severe coronavirus disease 2019 (COVID\u201019) infection. It continues to represent both a diagnostic and therapeutic challenge and can be associated with significant morbidity and mortality. In this narrative review, we describe the epidemiology, risk factors and disease manifestations of IPA. We discuss the latest evidence and current published guidelines for the diagnosis and management of IPA in the context of the critically ill within the ICU. Finally, we review influenza\u2010associated pulmonary aspergillosis (IAPA), COVID\u201019\u2010associated pulmonary aspergillosis (CAPA) as well as ongoing and future areas of research.<\/jats:p>","DOI":"10.1111\/apm.13316","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T10:28:15Z","timestamp":1680776895000},"page":"654-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Invasive pulmonary aspergillosis in the intensive care unit: current challenges and best practices"],"prefix":"10.1111","volume":"131","author":[{"given":"Sarah","family":"Gaffney","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO) St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dearbhla M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO) St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puteri Maisarah","family":"Rameli","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO) St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Martin\u2010Loeches","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO) St. James's Hospital  Dublin Ireland"},{"name":"Department of Clinical Medicine, School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"Hospital Clinic, Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) Universidad de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"e_1_2_16_2_1","first-page":"1366","article-title":"Overview: non\u2010fumigatus species of aspergillus: perspectives on emerging pathogens in immunocompromised hosts","volume":"2","author":"Walsh TJ","year":"2001","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200007000-00006"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-29"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/651262"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4578-y"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1065"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.40.1073"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc4823"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2003.15.1.71"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-093OC"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709544"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02044.x"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0722-7"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016060704"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2017.1340835"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802227159"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.03015.x"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/323335"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206291"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.01.001"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2004.19.1.38"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.631461"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30274-1"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-021-00827-3"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.749905"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S273946"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1103"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2673-2"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201612-2540LE"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201910-1931OC"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06431-0"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.08.014"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06449-4"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02278-20"},{"key":"e_1_2_16_37_1","first-page":"1631","article-title":"Navigating the uncertainties of covid\u201019\u2010associated aspergillosis: a comparison with influenza\u2010associated aspergillosis","volume":"224","author":"Lamoth F","year":"2021","journal-title":"J Infect Dis"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-1978OC"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.065"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06091-6"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30847-1"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00345-17"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(97)90833-1"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1086\/429921"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm463"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06423-11"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0255-x"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.12.3115-3118.1995"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.299-305.2005"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1865"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00942-12"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.1.139"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.157.3.3864189"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.t01-2-02002.x"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13465"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.09.011"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1086\/508774"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01159-9"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.Supplement_2.S133"},{"key":"e_1_2_16_63_1","first-page":"CD010481","article-title":"Amphotericin b deoxycholate versus liposomal amphotericin b: effects on kidney function","author":"Botero Aguirre JP","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.09.182"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1086\/514341"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565140-00009"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2508"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu581"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23109"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1086\/503844"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-824903"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)35813-1"},{"key":"e_1_2_16_73_1","unstructured":"Health protection surveillance Centre national guidelines for the prevention of nosocomial aspergillosis \u2013 a report of the aspergillosis subcommittee of the health protection surveillance Centre scientific advisory committee.2018."},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061098"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-16-4-145"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00579-5"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh1209"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6030122"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040239"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02280-16"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45890-w"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:56:57Z","timestamp":1697065017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":81,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/apm.13316"],"URL":"https:\/\/doi.org\/10.1111\/apm.13316","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]},"assertion":[{"value":"2023-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}