{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:43:18Z","timestamp":1793605398925,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p><jats:italic>Helicobacter Pylori<\/jats:italic> (<jats:italic>H.\u2009Pylori<\/jats:italic>) cause peptic ulcer disease (PUD), but the inflammasome's role in PUD is not well understood. Therefore this study has investigated inflammasome compartment expression and IL\u20101\u03b2 production in gastritis (G) and peptic ulcer disease. This study was based on gene expression of inflammasome compartments on stomach biopsies of 50 patients with PUD as cases and 50 individuals with gastritis as controls. The expression of NLRC4, ASC, IL\u201018, and serum IL\u20101\u03b2 decreased in the PUD group compared to the control group. AIM2 gene expression increased, and NLRP12 gene expression decreased in <jats:italic>H.\u2009pylori<\/jats:italic>\u2010seropositive positive (HP<jats:sup>+<\/jats:sup>) individuals compared to <jats:italic>H.\u2009pylori<\/jats:italic>\u2010seronegative (HP<jats:sup>\u2212<\/jats:sup>) individuals. The G\u2010HP<jats:sup>+<\/jats:sup> subjects had higher serum IL\u20101\u03b2 and AIM2 gene expression than G\u2010HP<jats:sup>\u2212<\/jats:sup> subjects but lower NLRP3 and NLRP12 gene expression. The PUD\u2010HP<jats:sup>+<\/jats:sup> had lower serum IL\u20101\u03b2, but higher AIM2 and IL\u201018 expression than PUD\u2010HP<jats:sup>\u2212<\/jats:sup>. The PUD\u2010HP<jats:sup>\u2212<\/jats:sup> patients had decreased IL\u201018 expression than G\u2010HP<jats:sup>\u2212<\/jats:sup> group. The PUD\u2010HP+ had lower serum IL\u20101\u03b2 and NLRC4 expression than G\u2010HP+, while NLRP1 and NLRP3 were higher in expression in PUD\u2010HP<jats:sup>+<\/jats:sup>. The expression of caspase\u20101, NLRP3 and NAIP were correlated with IL\u20101\u03b2 and IL\u201018. In conclusion, a decrease in NLRC4, IL\u201018, ASC genes, and IL\u20101\u03b2 levels in PUD patients compared to gastritis may act in the development of PUD. <jats:italic>H.\u2009pylori<\/jats:italic> caused AIM2 induction and reduced NLRP12, indicating their contribution to bacterial responses. Decreased NLRC4 expression and IL\u20101\u03b2 protein, together with enhanced NLRP1, and NLRP3 expression, promotes <jats:italic>H.\u2009pylori<\/jats:italic> to develop peptic ulcers.<\/jats:p>","DOI":"10.1111\/apm.13323","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T04:33:38Z","timestamp":1683866018000},"page":"339-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Elevated expression of the AIM2 gene in response to <i>Helicobacter pylori<\/i> along with the decrease of NLRC4 inflammasome is associated with peptic ulcer development"],"prefix":"10.1111","volume":"131","author":[{"given":"Fatemeh","family":"Davari","sequence":"first","affiliation":[{"name":"Student Research Committee Babol University of Medical Sciences  Babol 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