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Several antifungal drugs with distinct mechanisms of action are clinically approved for the treatment of fungal infections. The high rates of intrinsic and acquired drug resistance, particularly to azoles, reported in characterized clinical isolates of <jats:italic>C.\u2009auris<\/jats:italic> make treatment extremely problematic. In systemic infections, azoles are the first\u2010line treatment for most <jats:italic>Candida<\/jats:italic> species; however, the increasing use of drugs results in the frequent emergence of drug resistance. More than 90% of the clinical isolates of <jats:italic>C.\u2009auris<\/jats:italic> is shown to be highly resistant to azole drugs especially fluconazole, with some strains (types) resistant to all three classes of commonly used antifungals. This presents a huge challenge for researchers in terms of completely understanding the molecular mechanism of azole resistance to develop more efficient drugs. Due to the scarcity of <jats:italic>C.\u2009auris<\/jats:italic> therapeutic alternatives, the development of successful drug combinations provides an alternative for clinical therapy. Taking advantage of various action mechanisms, such drugs in combination with azole are likely to have synergistic effects, improving treatment efficacy and overcoming <jats:italic>C.\u2009auris<\/jats:italic> azole drug resistance. In this review, we outline the current state of understanding about the mechanisms of azole resistance mainly fluconazole, and the current advancement in therapeutic approaches such as drug combinations toward <jats:italic>C.\u2009auris<\/jats:italic> infections.<\/jats:p>","DOI":"10.1111\/apm.13336","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T08:54:50Z","timestamp":1687251290000},"page":"442-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Azole resistance in <i>Candida auris<\/i>: mechanisms and combinatorial therapy"],"prefix":"10.1111","volume":"131","author":[{"given":"Puneet","family":"Jangir","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Basic Sciences Central University of Punjab, VPO\u2010Ghudda  Bathinda 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