{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T21:59:47Z","timestamp":1709935187892},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30\u2010CA46934","P01\u2010CA58187","U01\u2010CA85070"],"award-info":[{"award-number":["P30\u2010CA46934","P01\u2010CA58187","U01\u2010CA85070"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Bronchial squamous carcinoma <jats:italic>in situ<\/jats:italic> (CIS) is a preinvasive lesion that is thought to precede invasive carcinoma. We conducted prospective autofluorescence and white light bronchoscopy trials between 1992 and 2016 to assess the prevalence, molecular markers, and outcome of individuals with CIS and other preneoplastic bronchial lesions. Biopsies were evaluated at multiple levels and selected biopsies were tested for aneuploidy and DNA sequenced for TP53 mutation. Thirty\u2010one individuals with CIS were identified. Twenty\u2010two cases of CIS occurred in association with concurrent invasive carcinomas. Seven of the invasive tumors were radiographically occult. In two cases, CIS spread from the focus of invasive carcinoma into contralateral lung lobes, forming secondary invasive tumors. In nine cases, CIS occurred as isolated lesions and one progressed to invasive squamous carcinoma at the same site 40\u2009months after discovery. In a second case, CIS was a precursor of carcinoma at a separate site in a different lobe. In seven cases CIS regressed to a lower grade or disappeared. High level chromosomal aneusomy was often associated with <jats:italic>TP53<\/jats:italic> mutation and with invasive carcinoma. CIS most often occurs in association with invasive squamous carcinoma and may extend along the airways into distant lobes. In rare cases, CIS may be observed to directly transform into invasive carcinoma. CIS may be indicative of invasive tumor at a separate distant site. Isolated CIS may regress. Molecular changes parallel histological changes in CIS and may be used to map clonal expansion in the airways.<\/jats:p>","DOI":"10.1111\/apm.13345","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:36:37Z","timestamp":1692776197000},"page":"513-527","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence, molecular markers, and outcome of bronchial squamous carcinoma <i>in situ<\/i> in <scp>high\u2010risk<\/scp>\u00a0subjects"],"prefix":"10.1111","volume":"131","author":[{"given":"Steinn","family":"Jonsson","sequence":"first","affiliation":[{"name":"Department of Medicine University of Colorado Health Sciences Center  Denver CO USA"},{"name":"Department of Medicine, Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilbur 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