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Infections with <jats:italic>C. albicans<\/jats:italic> and non\u2010albicans <jats:italic>Candida<\/jats:italic> species have become more common, especially in the past 20\u2009years, as a result of aging, immunosuppressive medication use, endocrine disorders, malnourishment, extended use of medical equipment, and an increase in immunogenic diseases. Despite <jats:italic>C. albicans<\/jats:italic> being the species most frequently associated with human infections, <jats:italic>C. glabrata<\/jats:italic>, <jats:italic>C. parapsilosis<\/jats:italic>, <jats:italic>C. tropicalis<\/jats:italic>, and <jats:italic>C. krusei<\/jats:italic> also have been identified. Several antifungal drugs with different modes of action are approved for use in clinical settings to treat fungal infections. However, due to the common eukaryotic structure of humans and fungi, only a limited number of antifungal drugs are available for therapeutic use. Furthermore, drug resistance in <jats:italic>Candida<\/jats:italic> species has emerged as a result of the growing use of currently available antifungal drugs against fungal infections. Amphotericin B (AmB), a polyene class of antifungal drugs, is mainly used for the treatment of serious systemic fungal infections. AmB interacts with fungal plasma membrane ergosterol, triggering cellular ion leakage via pore formation, or extracting the ergosterol from the plasma membrane inducing cellular death. AmB resistance is primarily caused by changes in the content or structure of ergosterol. 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