{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:38:47Z","timestamp":1791419927796,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>The vast majority of people with cystic fibrosis (pwCF) have untreated secondary chronic rhinosinusitis (CRS). Whereas the introduction of the cystic fibrosis transmembrane conductance regulator modulator (CFTRm) treatment regime has improved the lung function of pwCF, few studies have been published examining the effect on sinonasal symptoms in children. Our aim was to explore the effect of double CFTRm treatment on CRS and olfaction in children with CF. pwCF were included in this non\u2010randomized cross\u2010sectional study, where an otolaryngologist performed a complete ENT examination before initiating treatment with elaxacaftor\/tezacaftor\/ivacaftor (ETI). Twenty\u2010three pwCF aged 6\u201312\u2009years were included. Eighteen of 23 patients were on a double CFTRm treatment, and 5 patients were CFTRm naive, respectively. Altogether, 19 had normal olfaction, 20 had none or mild CRS symptoms according to SNOT\u201022, and 14 had a normal endoscopy. None of the patients had symptoms of chronic rhinosinusitis lasting for more than 12\u2009weeks, thus none of the patients fulfilled the criteria for CRS. Children with CF treated with double CFTRm have few to no symptoms of CRS and normal olfaction, which is an improvement compared with children following treatment modalities prior to CFTRm.<\/jats:p>","DOI":"10.1111\/apm.13427","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T02:08:55Z","timestamp":1716343735000},"page":"625-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The criteria for chronic rhinosinusitis in children with cystic fibrosis are rarely fulfilled after initiation of\n                    <scp>CFTR<\/scp>\n                    modulator treatment"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6471-0511","authenticated-orcid":false,"given":"Magne","family":"Bech","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery &amp; Audiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-8548","authenticated-orcid":false,"given":"Marianne","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents, CF Centre Copenhagen, Paediatric Pulmonary Service Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida S. 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