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Recently, high titer neutralizing anti\u2010type I interferon (IFN) autoantibodies have been linked with increased severity of SARS\u2010CoV\u20102 and <jats:italic>varicella zoster<\/jats:italic> virus infections in APECED patients. Examining immunity against cytomegalovirus (CMV), we found a higher prevalence of anti\u2010CMV IgG antibodies in patients with APECED (N\u2009=\u200919) than in 44 healthy controls (90% vs 64%, p\u2009=\u20090.04); the similar difference in their IgG levels did not achieve significance (95\u2009\u00b1\u200974 vs 64\u2009\u00b1\u200935\u2009IU\/mL, ns.). In contrast, the frequency of CMV\u2010specific T\u00a0cells was lower (804\u2009\u00b1\u2009718\/million vs 1591\u2009\u00b1\u2009972\/million PBMC p\u2009=\u20090.03). We saw no correlations between levels of anti\u2010CMV IgG and anti\u2010IFN antibodies in APECED patients or in a separate cohort of patients with thymoma (n\u2009=\u200970), over 60% of whom also had anti\u2010IFN antibodies. Our results suggest a dysregulated response to CMV in APECED patients and highlight immunodeficiency to viral infections as part of the disease spectrum.<\/jats:p>","DOI":"10.1111\/apm.13458","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T06:21:26Z","timestamp":1723098086000},"page":"881-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decreased T\u2010cell response against latent\u00a0cytomegalovirus infection does not correlate with anti\u2010IFN autoantibodies in patients with APECED"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-3549","authenticated-orcid":false,"given":"Iivo","family":"Hetem\u00e4ki","sequence":"first","affiliation":[{"name":"Translational Immunology Research Program University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelli","family":"Heikkil\u00e4","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4rt","family":"Peterson","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Translational Medicine University of Tartu  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliisa","family":"Kek\u00e4l\u00e4inen","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Clinical Microbiology, HUS Diagnostic Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Willcox","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Weatherall Institute for Molecular Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolff","family":"Anette S. 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